Enhancing the Anti‐Solvatochromic Two‐Photon Fluorescence for Cirrhosis Imaging by Forming a Hydrogen‐Bond Network

• Published in: Angewandte Chemie Vol. 130; no. 25; pp. 7595 - 7599
• Main Authors: Ren, Tian‐Bing, Xu, Wang, Zhang, Qian‐Ling, Zhang, Xing‐Xing, Wen, Si‐Yu, Yi, Hai‐Bo, Yuan, Lin, Zhang, Xiao‐Bing
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 18.06.2018
• Subjects: Antisolvatochromie; Biological properties; Biological samples; Biomedical materials; Chemical compounds; Chemistry; Chromophores; Cirrhosis; Dyes; Fluorescence; Fluoreszenzfarbstoffe; Fluorophores; Green fluorescent protein; Hydrogen bonding; Hydrogen bonds; Hydrogen sulfide; Imaging; Liver; Liver cirrhosis; Molecular chains; Proteins; Wasserstoffbrückennetzwerke; Zirrhose; Zweiphotonensonden

Two‐photon imaging is an emerging tool for biomedical research and clinical diagnostics. Electron donor–acceptor (D–A) type molecules are the most widely employed two‐photon scaffolds. However, current D–A type fluorophores suffer from solvatochromic quenching in aqueous biological samples. To addre...