Photothermally Triggered Copper Payload Release for Cuproptosis‐Promoted Cancer Synergistic Therapy

• Published in: Angewandte Chemie Vol. 135; no. 12
• Main Authors: Zhou, Jie, Yu, Qiao, Song, Juan, Li, Shan, Li, Xiang‐Ling, Kang, Bin K., Chen, Hong‐Yuan, Xu, Jing‐Juan
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 13.03.2023
• Subjects: Apoptosis; Cancer; Cell death; Chemistry; Copper; Copper Delivery; Cuproptosis; Cytotoxicity; Disulfiram; Gold; Growth inhibition; Mitochondria; Nanostructures; Photothermally Triggered Release; Protein interaction; Synergistic Therapy; Therapy; Tumor cells; Tumors

Cuproptosis is a new form of programmed cell death and exhibits enormous potential in cancer treatment. However, reducing the undesirable Cu ion release in normal tissue and maximizing the copper‐induced therapeutic effect in cancer sites are two main challenges. In this study, we constructed a phot...