Ruthenium‐Containing Linear Helicates and Mesocates with Tuneable p53‐Selective Cytotoxicity in Colorectal Cancer Cells

• Published in: Angewandte Chemie Vol. 130; no. 31; pp. 9947 - 9952
• Main Authors: Allison, Simon J., Cooke, David, Davidson, Francesca S., Elliott, Paul I. P., Faulkner, Robert A., Griffiths, Hollie B. S., Harper, Owen J., Hussain, Omar, Owen‐Lynch, P. Jane, Phillips, Roger M., Rice, Craig R., Shepherd, Samantha L., Wheelhouse, Richard T.
• Format: Journal Article
• Language: English; German
• Published: Weinheim Wiley Subscription Services, Inc 26.07.2018
• Subjects: Cancer; Chemistry; Colorectal carcinoma; Cytotoxicity; Helikate; Krebs; Ligands; Mesocate; p53 Protein; Ruthenium; Selectivity; Toxicity; Tumors; Zytotoxizität

The ligands L1 and L2 both form separable dinuclear double‐stranded helicate and mesocate complexes with RuII. In contrast to clinically approved platinates, the helicate isomer of [Ru2(L1)2]4+ was preferentially cytotoxic to isogenic cells (HCT116 p53−/−), which lack the critical tumour suppressor...