Rh-III-Catalyzed formal [5+1] cyclization of 2-pyrrolyl/indolylanilines using vinylene carbonate as a C1 synthon

• Published in: ORGANIC CHEMISTRY FRONTIERS Vol. 8; no. 8; pp. 1764 - 1769
• Main Authors: Nan, Jiang, Ma, Qiong, Yin, Jiacheng, Liang, Chengyuan, Tian, Lei, Ma, Yangmin
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 21.04.2021
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; METAL-FREE SYNTHESIS; ROUTE; ACTIVATION; AMINATION; ANNULATION; ANILINES; EFFICIENT SYNTHESIS; QUINOLINES; C(SP)-H; ALKENYLATION

A rhodium(iii)-catalyzed formal C-H [5 + 1] cyclization of 2-pyrrolyl/indolylanilines with vinylene carbonate has been explored towards the potent assembly of diverse 4-methylpyrrolo[1,2-a]quinoxalines. This established protocol is characterized by an exceedingly simple reaction system, and excellen...