Rare Case of Alternative Splicing Form Caused By L248V Mutation in CML Patient

• Published in: Blood Vol. 126; no. 23; p. 5139
• Main Authors: Butylin, Pavel, Matyuhina, Natalia, Siordia, Nadia, Lomaya, Elza, Zaritskey, Andrey
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2015

Clinical data: Subject: Male, 45 years old, diagnosed in 2001 with Ph+ CMLCP (low Sokalrisk).From 2001 to 2005 he was treated with Hydrea and Interferon with low dose Cytarabine. In 2005 he was switched to imatinib 400 mg/day. Due to cytogenetic resistance Imatinib dose was escalated to 600mg/day in...