PF-04449913 Reverts Multi Drug Resistance (MDR) by a Strong Down-Regulation of ABCA2 and BCL2 on Leukemia Stem Cells in Phase I Acute Myeloid Leukemia and Chronic Myeloid Leukemia Treated Patients

• Published in: Blood Vol. 118; no. 21; p. 1429
• Main Authors: Papayannidis, Cristina, Guadagnuolo, Viviana, Iacobucci, Ilaria, Durante, Sandra, Terragna, Carolina, Ottaviani, Emanuela, Abbenante, Maria Chiara, Cattina, Federica, Soverini, Simona, Lama, Barbara, Toni, Lucia, Levin, Wendy J., Courtney, Rachel, Baldazzi, Carmen, Curti, Antonio, Baccarani, Michele, Jamieson, Catriona, Cortes, Jorge E., Oehler, Vivian, McLachlan, Karen, Van Arsdale, Todd, Martinelli, Giovanni
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 18.11.2011

Abstract 1429 The development of resistance against chemotherapy remains one of the major challenges in the clinical management of leukemia. The Sonic Hedgehog (Hh) pathway is an essential regulator of multidrug resistance (MDR) in leukemia by exerting it's effect on leukaemia stem cells (LSC)....