ICOS Gene Polymorphisms In B-Cell Chronic Lymphocytic Leukemia In a Polish Population

• Published in: Blood Vol. 116; no. 21; p. 4614
• Main Authors: Frydecka, Irena, Karabon, Lidia, Jedynak, Anna, Tomkiewicz, Anna, Pawlak, Edyta, Wolowiec, Dariusz, Kielbinski, Marek, Kuliczkowski, Kazimierz, Woszczyk, Dariusz, Wrobel, Tomasz
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 19.11.2010

Abstract 4614 There is strong evidence that altered immunological function entails an increased risk of B-cell chronic lymphocytic leukemia (B-CLL). The main mechanism of an antitumor response depends on T-cell activation. Unlike the constitutively expressed CD28, inducible costimulatory molecule (I...