Up-Regulation of miR-195 Expression Leads to Decreased Expression of Basic Fibroblast Growth Factor in CLL Patients Treated with DNA Methylation Inhibitors

• Published in: Blood Vol. 110; no. 11; p. 3183
• Main Authors: Phillips, John D., Pop, Ioana, Boucher, Ken, Yu, Margaret K.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.11.2007

A higher than age-expected DNA methylation index is predictive for early disease progression in patients with CLL (Yu et al. Leukemia Research 2006). We hypothesized that miRNA expression can also be silenced by promoter hypermethylation in CLL. Thus, methyl pool or DNA methyltransferase inhibitors...