Identification of Causal and/or Rare Genetic Variants for Complex Traits by Targeted Resequencing in Population-based Cohorts

• Published in: Genomics & informatics Vol. 8; no. 3; pp. 131 - 137
• Main Authors: Kim, Yun-Kyoung, Hong, Chang-Bum, Cho, Yoon-Shin
• Format: Journal Article
• Language: English
• Published: 한국유전체학회 30.09.2010
• Subjects: 자연과학일반

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SN...