PD-1 Is Elevated on the Peripheral Blood T Cell Subsets of Patients with Relapsed/Refractory Hodgkin Lymphoma Compared to Normal Volunteers

• Published in: Blood Vol. 118; no. 21; p. 4860
• Main Authors: Diefenbach, Catherine S., Sabado, Rachel, Clark-Garvey, Sean, Cruz, Crystal, Vengco, Isabelita, Rojas, Celeste N, Serrano, Victoria, Zain, Jasmine M., Cho, Hearn J., O'Connor, Owen A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 18.11.2011

Abstract 4860 Programmed death-1(PD-1) and programmed death-1 ligand (PD-L) signaling are involved in the functional impairment and “exhaustion” of T cells in conditions such as chronic viral infection and in tumor immune evasion. The interaction of PD-1 with its ligand PD-L suppresses T cell functi...