T 2 relaxation reveals spatial collagen architecture in articular cartilage: A comparative quantitative MRI and polarized light microscopic study
Abstract It has been suggested that orientational changes in the collagen network of articular cartilage account for the depthwise T 2 anisotropy of MRI through the magic angle effect. To investigate the relationship between laminar T 2 appearance and collagen organization (anisotropy), bovine osteo...
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| Published in | Magnetic resonance in medicine Vol. 46; no. 3; pp. 487 - 493 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.09.2001
|
| Online Access | Get full text |
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| Abstract | Abstract
It has been suggested that orientational changes in the collagen network of articular cartilage account for the depthwise
T
2
anisotropy of MRI through the magic angle effect. To investigate the relationship between laminar
T
2
appearance and collagen organization (anisotropy), bovine osteochondral plugs (
N
= 9) were
T
2
mapped at 9.4T with cartilage surface normal to the static magnetic field. Collagen fibril arrangement of the same samples was studied with polarized light microscopy, a quantitative technique for probing collagen organization by analyzing its ability to rotate plane polarized light, i.e., birefringence (BF). Depthwise variation of safranin O‐stained proteoglycans was monitored with digital densitometry. The spatially varying cartilage
T
2
followed the architectural arrangement of the collagen fibril network: a linear positive correlation between
T
2
and the reciprocal of BF was established in each sample, with
r
= 0.91 ±
0.02 (mean ± SEM,
N
= 9). The current results reveal the close connection between the laminar
T
2
structure and the collagen architecture in histologic zones. Magn Reson Med 46:487–493, 2001. © 2001 Wiley‐Liss, Inc. |
|---|---|
| AbstractList | Abstract
It has been suggested that orientational changes in the collagen network of articular cartilage account for the depthwise
T
2
anisotropy of MRI through the magic angle effect. To investigate the relationship between laminar
T
2
appearance and collagen organization (anisotropy), bovine osteochondral plugs (
N
= 9) were
T
2
mapped at 9.4T with cartilage surface normal to the static magnetic field. Collagen fibril arrangement of the same samples was studied with polarized light microscopy, a quantitative technique for probing collagen organization by analyzing its ability to rotate plane polarized light, i.e., birefringence (BF). Depthwise variation of safranin O‐stained proteoglycans was monitored with digital densitometry. The spatially varying cartilage
T
2
followed the architectural arrangement of the collagen fibril network: a linear positive correlation between
T
2
and the reciprocal of BF was established in each sample, with
r
= 0.91 ±
0.02 (mean ± SEM,
N
= 9). The current results reveal the close connection between the laminar
T
2
structure and the collagen architecture in histologic zones. Magn Reson Med 46:487–493, 2001. © 2001 Wiley‐Liss, Inc. |
| Author | Töyräs, Juha Nieminen, Miika T. Rieppo, Jarno Hakumäki, Juhana M. Jurvelin, Jukka S. Silvennoinen, Johanna Hyttinen, Mika M. Helminen, Heikki J. |
| Author_xml | – sequence: 1 givenname: Miika T. surname: Nieminen fullname: Nieminen, Miika T. – sequence: 2 givenname: Jarno surname: Rieppo fullname: Rieppo, Jarno – sequence: 3 givenname: Juha surname: Töyräs fullname: Töyräs, Juha – sequence: 4 givenname: Juhana M. surname: Hakumäki fullname: Hakumäki, Juhana M. – sequence: 5 givenname: Johanna surname: Silvennoinen fullname: Silvennoinen, Johanna – sequence: 6 givenname: Mika M. surname: Hyttinen fullname: Hyttinen, Mika M. – sequence: 7 givenname: Heikki J. surname: Helminen fullname: Helminen, Heikki J. – sequence: 8 givenname: Jukka S. surname: Jurvelin fullname: Jurvelin, Jukka S. |
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| DBID | AAYXX CITATION |
| DOI | 10.1002/mrm.1218 |
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| References | e_1_2_7_5_2 e_1_2_7_4_2 Meachim G (e_1_2_7_37_2) 1979 e_1_2_7_3_2 e_1_2_7_2_2 e_1_2_7_9_2 e_1_2_7_8_2 e_1_2_7_7_2 Hopwood D (e_1_2_7_35_2) 1977 e_1_2_7_6_2 e_1_2_7_19_2 e_1_2_7_18_2 e_1_2_7_17_2 e_1_2_7_16_2 e_1_2_7_15_2 e_1_2_7_14_2 e_1_2_7_40_2 e_1_2_7_13_2 e_1_2_7_12_2 e_1_2_7_42_2 e_1_2_7_11_2 e_1_2_7_43_2 e_1_2_7_10_2 e_1_2_7_26_2 e_1_2_7_27_2 e_1_2_7_28_2 e_1_2_7_29_2 e_1_2_7_25_2 e_1_2_7_24_2 e_1_2_7_30_2 e_1_2_7_23_2 e_1_2_7_31_2 e_1_2_7_22_2 e_1_2_7_32_2 e_1_2_7_21_2 e_1_2_7_33_2 e_1_2_7_20_2 e_1_2_7_34_2 e_1_2_7_36_2 Bennett HS (e_1_2_7_41_2) 1950 e_1_2_7_38_2 e_1_2_7_39_2 |
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T
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| Title | T 2 relaxation reveals spatial collagen architecture in articular cartilage: A comparative quantitative MRI and polarized light microscopic study |
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