Cribado combinado del síndrome de Down: validación del riesgo estimado por Fetaltest
Resumen Objetivo Validar empíricamente el riesgo de síndrome de Down estimado por Fetaltest usando marcadores bioquímicos del primer trimestre (la proteína A asociada al embarazo [PAPP-A] y subunidad beta libre de la gonadotropina coriónica humana [HCG]) y translucencia nucal (TN). Material y método...
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| Published in | Progresos de obstetricia y ginecología Vol. 52; no. 3; pp. 133 - 137 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | Spanish |
| Published |
Elsevier Espana
01.03.2009
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Resumen Objetivo Validar empíricamente el riesgo de síndrome de Down estimado por Fetaltest usando marcadores bioquímicos del primer trimestre (la proteína A asociada al embarazo [PAPP-A] y subunidad beta libre de la gonadotropina coriónica humana [HCG]) y translucencia nucal (TN). Material y métodos Estudio retrospectivo de los 15.009 cribados combinados del primer trimestre, incluidos en la base de datos mantenida prospectivamente por el estudio multicéntrico Fetaltest, y finalizados antes de 31 de diciembre de 2007. El estudio incluye 39 casos de síndrome de Down detectados pre o posnatalmente y usó un método de análisis previamente establecido. Resultados La correlación entre el riesgo predicho y la prevalencia observada de síndrome de Down fue muy alta (r = 0,999967). Conclusiones El riesgo estimado por el sistema de cálculo de Fetaltest concuerda muy fielmente con la prevalencia de síndrome de Down observada, por lo que este sistema de cálculo es válido y puede usarse con tranquilidad en la atención de gestantes de nuestro entorno. |
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| AbstractList | Resumen Objetivo Validar empíricamente el riesgo de síndrome de Down estimado por Fetaltest usando marcadores bioquímicos del primer trimestre (la proteína A asociada al embarazo [PAPP-A] y subunidad beta libre de la gonadotropina coriónica humana [HCG]) y translucencia nucal (TN). Material y métodos Estudio retrospectivo de los 15.009 cribados combinados del primer trimestre, incluidos en la base de datos mantenida prospectivamente por el estudio multicéntrico Fetaltest, y finalizados antes de 31 de diciembre de 2007. El estudio incluye 39 casos de síndrome de Down detectados pre o posnatalmente y usó un método de análisis previamente establecido. Resultados La correlación entre el riesgo predicho y la prevalencia observada de síndrome de Down fue muy alta (r = 0,999967). Conclusiones El riesgo estimado por el sistema de cálculo de Fetaltest concuerda muy fielmente con la prevalencia de síndrome de Down observada, por lo que este sistema de cálculo es válido y puede usarse con tranquilidad en la atención de gestantes de nuestro entorno. Validar empíricamente el riesgo de síndrome de Down estimado por Fetaltest usando marcadores bioquímicos del primer trimestre (la proteína A asociada al embarazo [PAPP-A] y subunidad beta libre de la gonadotropina coriónica humana [HCG]) y translucencia nucal (TN). Estudio retrospectivo de los 15.009 cribados combinados del primer trimestre, incluidos en la base de datos mantenida prospectivamente por el estudio multicéntrico Fetaltest, y finalizados antes de 31 de diciembre de 2007. El estudio incluye 39 casos de síndrome de Down detectados pre o posnatalmente y usó un método de análisis previamente establecido. La correlación entre el riesgo predicho y la prevalencia observada de síndrome de Down fue muy alta (r=0,999967). El riesgo estimado por el sistema de cálculo de Fetaltest concuerda muy fielmente con la prevalencia de síndrome de Down observada, por lo que este sistema de cálculo es válido y puede usarse con tranquilidad en la atención de gestantes de nuestro entorno. To validate empirically the risk for Down syndrome estimated by Fetaltest using biochemical markers in the first trimester (PAPP-A and free beta subunit of hCG) and nuchal translucency. We performed a retrospective study of the data from 15,009 pregnant women screened for Down Syndrome in the first trimester, included in the database prospectively maintained by the Fetaltest multicenter study, and completed before December 31, 2007. The study included 39 cases of Down syndrome detected either prenatally or postnatally, and used a previously established analysis method. The correlation between predicted risk and the observed prevalence of Down syndrome was very high (r=0.999967). The risk estimated by Fetaltest agrees closely with the observed prevalence of Down syndrome. Therefore, this calculation system is valid and can be used with confidence when counseling pregnant women in our environment. |
| Author | Bajo Arenas, José Manuel Santiago Blázquez, Juan Carlos Ramos-Corpas, Domingo Jesús Gallo Vallejo, Manuel |
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| Cites_doi | 10.1111/j.1471-0528.2004.00193.x 10.1177/000456329903600115 10.1053/j.semperi.2005.05.004 10.1002/(SICI)1097-0223(199911)19:11<1083::AID-PD686>3.0.CO;2-L 10.1002/uog.5171 10.1002/(SICI)1097-0223(199809)18:9<956::AID-PD370>3.0.CO;2-R 10.1016/S0140-6736(97)11280-6 10.1002/pd.312 10.1002/(SICI)1097-0223(199902)19:2<142::AID-PD486>3.0.CO;2-7 10.3310/hta7110 10.1002/(SICI)1097-0223(199804)18:4<413::AID-PD260>3.0.CO;2-Y 10.1002/pd.966 10.1002/pd.134 10.1002/pd.1568 10.1177/096914139600300405 10.1111/j.1471-0528.1987.tb03115.x 10.1053/j.semperi.2005.05.006 |
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| Keywords | Validation Prevalence Síndrome de Down Prevalencia Validación Cribado prenatal Estimación del riesgo Risk estimate Prenatal screening Down syndrome |
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| References | Ramos Corpas, Gallo Vallejo, Santiago Blázquez (bb0105) 2005; 17 Wald, Rodeck, Hackshaw, Walters, Chitty, Mackinson (bb0005) 2003; 7 Cuckle, Benn, Wright (bb0015) 2005; 29 Santiago, Ramos-Corpas (bb0100) 2007; 30 Wald, Rodeck, Hackshaw, Rudnicka (bb0080) 2004; 24 Ramos-Corpas, Santiago (bb0020) 2006; 26 Santiago Blázquez, Ramos Corpas, Gallo Vallejo (bb0060) 2005; 17 Spencer (bb0055) 2002; 22 Snijders, Sundberg, Holzgreve, Henry, Nicolaides (bb0070) 1999; 156 Onda, Tanaka, Takeda, Kitagawa, Kuwabara, Yamamoto (bb0040) 1998; 18 Wald, Huttly (bb0035) 1999; 19 Ramos Corpas, Gallo Vallejo, Santiago Blázquez (bb0065) 2005; 17 Canick, Rish (bb0030) 1998; 18 Wald, Rodeck, Hackshaw, Rudnicka (bb0075) 2004; 111 Snijders, Noble, Sebire, Souka, Nicolaides (bb0050) 1998; 352 Wald, Hackshaw, Huttly, Kennard (bb0025) 1996; 3 Spencer (bb0045) 1999; 36 Cuckle, Wald, Thompson (bb0010) 1987; 94 Morris, Wald, Watt (bb0090) 1999; 19 Wald, Rodeck, Hackshaw, Rudnicka (bb0085) 2005; 29 Spencer (bb0095) 2001; 21 Ramos Corpas (10.1016/S0304-5013(09)70616-8_bb0065) 2005; 17 Morris (10.1016/S0304-5013(09)70616-8_bb0090) 1999; 19 Santiago (10.1016/S0304-5013(09)70616-8_bb0100) 2007; 30 Spencer (10.1016/S0304-5013(09)70616-8_bb0055) 2002; 22 Wald (10.1016/S0304-5013(09)70616-8_bb0075) 2004; 111 Spencer (10.1016/S0304-5013(09)70616-8_bb0095) 2001; 21 Canick (10.1016/S0304-5013(09)70616-8_bb0030) 1998; 18 Santiago Blázquez (10.1016/S0304-5013(09)70616-8_bb0060) 2005; 17 Cuckle (10.1016/S0304-5013(09)70616-8_bb0015) 2005; 29 Onda (10.1016/S0304-5013(09)70616-8_bb0040) 1998; 18 Wald (10.1016/S0304-5013(09)70616-8_bb0085) 2005; 29 Wald (10.1016/S0304-5013(09)70616-8_bb0005) 2003; 7 Ramos-Corpas (10.1016/S0304-5013(09)70616-8_bb0020) 2006; 26 Wald (10.1016/S0304-5013(09)70616-8_bb0025) 1996; 3 Wald (10.1016/S0304-5013(09)70616-8_bb0035) 1999; 19 Spencer (10.1016/S0304-5013(09)70616-8_bb0045) 1999; 36 Snijders (10.1016/S0304-5013(09)70616-8_bb0050) 1998; 352 Ramos Corpas (10.1016/S0304-5013(09)70616-8_bb0105) 2005; 17 Snijders (10.1016/S0304-5013(09)70616-8_bb0070) 1999; 156 Cuckle (10.1016/S0304-5013(09)70616-8_bb0010) 1987; 94 Wald (10.1016/S0304-5013(09)70616-8_bb0080) 2004; 24 |
| References_xml | – volume: 29 start-page: 225 year: 2005 end-page: 235 ident: bb0085 article-title: SURUSS in perspective publication-title: Semin Perinatol contributor: fullname: Rudnicka – volume: 17 start-page: 46 year: 2005 end-page: 48 ident: bb0060 article-title: Desarrollo y evaluación de un sistema logístico para la implantación clínica del cribado combinado (ecográfico y bioquímico) de cromosomopatías en el primer trimestre de la gestación. 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Fetal Medicine Foundation First Trimester Screening Group publication-title: Lancet doi: 10.1016/S0140-6736(97)11280-6 contributor: fullname: Snijders – volume: 22 start-page: 244 year: 2002 ident: 10.1016/S0304-5013(09)70616-8_bb0055 article-title: Accuracy of Down syndrome risks produced in a first-trimester screening programme incorporating fetal nuchal translucency thickness and maternal serum biochemistry publication-title: Prenat Diagn doi: 10.1002/pd.312 contributor: fullname: Spencer – volume: 19 start-page: 142 year: 1999 ident: 10.1016/S0304-5013(09)70616-8_bb0090 article-title: Fetal loss in Down syndrome pregnancies publication-title: Prenat Diagn doi: 10.1002/(SICI)1097-0223(199902)19:2<142::AID-PD486>3.0.CO;2-7 contributor: fullname: Morris – volume: 7 start-page: 1 year: 2003 ident: 10.1016/S0304-5013(09)70616-8_bb0005 article-title: SURUSS Research Group. First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS) publication-title: Health Technol Assess doi: 10.3310/hta7110 contributor: fullname: Wald – volume: 18 start-page: 413 year: 1998 ident: 10.1016/S0304-5013(09)70616-8_bb0030 article-title: The accuracy of assigned risks in maternal serum screening publication-title: Prenat Diagn doi: 10.1002/(SICI)1097-0223(199804)18:4<413::AID-PD260>3.0.CO;2-Y contributor: fullname: Canick – volume: 24 start-page: 835 year: 2004 ident: 10.1016/S0304-5013(09)70616-8_bb0080 article-title: Correlations between nuchal translucency and serum markers in SURUSS publication-title: Prenat Diagn doi: 10.1002/pd.966 contributor: fullname: Wald – volume: 21 start-page: 788 year: 2001 ident: 10.1016/S0304-5013(09)70616-8_bb0095 article-title: What is the true fetal loss rate in pregnancies affected by trisomy 21 and how does this influence whether first trimester detection rates are superior to those in the second trimester? publication-title: Prenat Diagn doi: 10.1002/pd.134 contributor: fullname: Spencer – volume: 26 start-page: 1124 year: 2006 ident: 10.1016/S0304-5013(09)70616-8_bb0020 article-title: Single large study or meta-analysis parameters: choosing the most appropriate tool for Down syndrome screening in the first trimester publication-title: Prenat Diagn doi: 10.1002/pd.1568 contributor: fullname: Ramos-Corpas – volume: 17 start-page: 46 year: 2005 ident: 10.1016/S0304-5013(09)70616-8_bb0060 article-title: Desarrollo y evaluación de un sistema logístico para la implantación clínica del cribado combinado (ecográfico y bioquímico) de cromosomopatías en el primer trimestre de la gestación. Proyecto Fetaltest publication-title: Progr Diag Trat Prenat contributor: fullname: Santiago Blázquez – volume: 17 start-page: 32 year: 2005 ident: 10.1016/S0304-5013(09)70616-8_bb0065 article-title: Cálculo del riesgo de cromosomopatías en el cribado combinado del primer trimestre publication-title: Progr Diag Trat Prenat contributor: fullname: Ramos Corpas – volume: 3 start-page: 185 year: 1996 ident: 10.1016/S0304-5013(09)70616-8_bb0025 article-title: Empirical validation of risk screening for Down s syndrome publication-title: J Med Screen doi: 10.1177/096914139600300405 contributor: fullname: Wald – volume: 94 start-page: 387 year: 1987 ident: 10.1016/S0304-5013(09)70616-8_bb0010 article-title: Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha-fetoprotein level publication-title: Br J Obstet Gynaecol doi: 10.1111/j.1471-0528.1987.tb03115.x contributor: fullname: Cuckle – volume: 29 start-page: 225 year: 2005 ident: 10.1016/S0304-5013(09)70616-8_bb0085 article-title: SURUSS in perspective publication-title: Semin Perinatol doi: 10.1053/j.semperi.2005.05.006 contributor: fullname: Wald |
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| SubjectTerms | Cribado prenatal Down syndrome Estimación del riesgo Obstetrics and Gynecology Prenatal screening Prevalence Prevalencia Risk estimate Síndrome de Down Validación Validation |
| Title | Cribado combinado del síndrome de Down: validación del riesgo estimado por Fetaltest |
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