An Indocyanine Green‐Based Nanoprobe for In Vivo Detection of Cellular Senescence

• Published in: Angewandte Chemie Vol. 136; no. 25
• Main Authors: Baker, Andrew G., Hartono, Muhamad, Ou, Hui‐Ling, Popov, Andrea Bistrović, Brown, Emma L., Joseph, James, Golinska, Monika, González‐Gualda, Estela, Macias, David, Ge, Jianfeng, Denholm, Mary, Morsli, Samir, Sanghera, Chandan, Else, Thomas R., Greer, Heather F., Vernet, Aude, Bohndiek, Sarah E., Muñoz‐Espín, Daniel, Fruk, Ljiljana
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 17.06.2024
• Subjects: Biocompatibility; Cancer; Cancer therapies; Cellular senescence; Chemotherapy; Development strategies; endocytosis; ICG nanoprobe; In vivo methods and tests; Lysosomes; Manufacturing industry; Metastases; Photoacoustic effect; photoacoustic tomography (PAT); Radiation therapy; Self-assembly; Senescence; Side effects; Solid tumors; Spectral signatures

There is an urgent need to improve conventional cancer‐treatments by preventing detrimental side effects, cancer recurrence and metastases. Recent studies have shown that presence of senescent cells in tissues treated with chemo‐ or radiotherapy can be used to predict the effectiveness of cancer tre...