Copper‐Catalyzed Chemo‐ and Enantioselective Radical 1,2‐Carbophosphonylation of Styrenes

• Published in: Angewandte Chemie Vol. 135; no. 13
• Main Authors: Zhou, Huan, Fan, Li‐Wen, Ren, Yang‐Qing, Wang, Li‐Lei, Yang, Chang‐Jiang, Gu, Qiang‐Shuai, Li, Zhong‐Liang, Liu, Xin‐Yuan
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 20.03.2023
• Subjects: Alkene; Alkenes; Asymmetric Catalysis; Catalysts; Chemistry; Chiral α-Alkyl Phosphonates; Copper; Electron transfer; Enantiomers; Energy of dissociation; Free energy; Halides; Heat of formation; Hydrogen bonds; Inorganic salts; Ligands; Phosphorus; Phosphorus compounds; Radical Chemistry; Reagents; Styrenes

The copper‐catalyzed enantioselective radical difunctionalization of alkenes from readily available alkyl halides and organophosphorus reagents possessing a P−H bond provides an appealing approach for the synthesis of α‐chiral alkyl phosphorus compounds. The major challenge arises from the easy gene...