Cardiohemodynamic effects of MS-857 in pacing induced heart failure

• Published in: Japanese Journal of Pharmacology Vol. 64; no. suppl.1; p. 266
• Main Authors: Hori, Katsuhiko, Suga, Hiroyuki, Maruyama, Masahiko, Kamiya, Joji
• Format: Journal Article
• Language: Japanese; English
• Published: The Japanese Pharmacological Society 1994

Beneficial effects of MS-857, an orally active phosphodiesterase III inhibitor, have been demonstrated on the failing heart in several canine acute heart failure models. In the present study, we studied the effects of MS-857 on cardiac contractility and hemodynamics in a conscious canine pacing indu...