Variants in mannose-binding lectin and tumour necrosis factor   affect survival in cystic fibrosis

• Published in: Journal of medical genetics Vol. 44; no. 3; pp. 209 - 214
• Main Authors: Buranawuti, K., Boyle, M. P, Cheng, S., Steiner, L. L, McDougal, K., Fallin, M D., Merlo, C., Zeitlin, P. L, Rosenstein, B. J, Mogayzel, P. J, Wang, X., Cutting, G. R
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group LTD 01.03.2007
• Subjects: Adults; Age; Cystic fibrosis; Cytokines; Gangrene; Genes; Growth factors; Lung diseases; Mortality; Statistical analysis; Survival analysis; Tumor necrosis factor-TNF

Background: Patients with cystic fibrosis with the same mutations in the cystic fibrosis transmembrane conductance regulator (CFTR ) gene differ widely in survival suggesting other factors have a substantial role in mortality. Objective: To determine if the genotype distribution of variants in three...