H19 lnc RNA alters stromal cell growth via IGF signaling in the endometrium of women with endometriosis

• Published in: EMBO molecular medicine Vol. 7; no. 8; pp. 996 - 1003
• Main Authors: Ghazal, Sanaz, McKinnon, Brett, Zhou, Jichun, Mueller, Martin, Men, Yi, Yang, Lihua, Mueller, Michael, Flannery, Clare, Huang, Yingqun, Taylor, Hugh S
• Format: Journal Article
• Language: English
• Published: Frankfurt EMBO Press 01.08.2015
• Subjects: Bioavailability; Cell growth; Cell proliferation; Chronic pain; Drug development; Endometriosis; Endometrium; Experiments; Gene expression; Infertility; Insulin; Insulin-like growth factors; Menstruation; MicroRNAs; miRNA; Molecular modelling; Physiology; Pregnancy; Signal transduction; Software; Stromal cells; Transcription

Endometriosis affects approximately 15% of reproductive aged women and is associated with chronic pelvic pain and infertility. However, the molecular mechanisms by which endometriosis impacts fertility are poorly understood. The developmentally regulated, imprinted H19 long noncoding RNA (lncRNA) fu...