ChemInform Abstract: Isoquinoline Derivatives as Potent CRTH2 Receptor Antagonists: Synthesis and SAR

The most potent compound, TASP0376377 (I) shows good CRTH2 antagonist potency, as well as sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor and COX‐1 and COX‐2 enzymes.

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Bibliographic Details
Published inChemInform Vol. 43; no. 38; p. no
Main Authors Nishikawa-Shimono, Rie, Sekiguchi, Yoshinori, Koami, Takeshi, Kawamura, Madoka, Wakasugi, Daisuke, Watanabe, Kazuhito, Wakahara, Shunichi, Matsumoto, Kayo, Takayama, Tetsuo
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 18.09.2012
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Immunology
isoquinoline derivatives
receptor binding activity
structure-activity relationship
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Summary:The most potent compound, TASP0376377 (I) shows good CRTH2 antagonist potency, as well as sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor and COX‐1 and COX‐2 enzymes.
Bibliography:ark:/67375/WNG-B03H7948-4
ArticleID:CHIN201238144
istex:82085CEBD548B06DE95FC90A9DCDB66890FF8BD5
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201238144