Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats

• Published in: Pharmaceutical sciences Asia Vol. 49; no. 2; pp. 129 - 137
• Main Authors: Kolibea Mante, Priscilla, Abakah-Ewusi, Kweku, Adoley Mingle, Amanda, Seidu Kpienaan, Mustapha, Offei-Twum, Samuel, Kofi Kusi-Boadum, Nana, Adomako, Nana Ofori, Osafo, Newman
• Format: Journal Article
• Language: English
• Published: Faculty of Pharmacy, Mahidol University 01.03.2022
• Subjects: delta opioid receptor; naloxone; pain; xylopia; xylopic acid

Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheumatism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia aethiopica, to cause tolerance when administered...