Antibiotic susceptibility and genotypic characterization of Neisseria gonorrhoeae isolates in the Comunidad Valenciana (Spain): GONOvig project
The increase in sexually transmitted infections (STI) caused by Neisseria gonorrhoeae (NG) worldwide, together with the decrease in antibiotic susceptibility, forced us to understand the epidemiology of gonococcal infection. The GONOvig project analyzed, comparatively following CLSI and EUCAST crite...
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Published in | Enfermedades infecciosas y microbiologia clinica (English ed.) Vol. 42; no. 2; pp. 69 - 73 |
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Format | Journal Article |
Language | English |
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Elsevier España, S.L.U
01.02.2024
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Abstract | The increase in sexually transmitted infections (STI) caused by Neisseria gonorrhoeae (NG) worldwide, together with the decrease in antibiotic susceptibility, forced us to understand the epidemiology of gonococcal infection.
The GONOvig project analyzed, comparatively following CLSI and EUCAST criteria, the antibiotic susceptibility of 227 NG strains collected in thirteen representative hospitals of the Valencia Community (CV) between 2013 and 2018. Additionally, molecular typing of 175 strains using the NG multi-antigen sequence typing technique (NG-MAST) was performed.
High rates of resistance to tetracycline (38.2% by CLSI and 50.9% by EUCAST) and ciprofloxacin (49.1% CLSI and 54% EUCAST), and low percentages of resistance to spectinomycin (0%), cefixime (0.5% CLSI but 5.9% EUCAST), and ceftriaxone (1.5% CLSI and 2.4% EUCAST) were detected. Azithromycin resistance was 6% (both CLSI and EUCAST). Molecular analysis revealed the presence of 86 different sequence types (ST), highlighting ST2992 (7.4%), ST3378 (6.9%), ST2400 (4.6%) and ST13288 (6.9%), which was associated with resistance to cefixime (P=.031). The main genogroups (G) were G1407 (13.1%), G2992 (10.3%), G2400 (6.3%) and G387 (3.4%). G1407 and G2400 were associated with resistance to ciprofloxacin (P<.03).
Low resistance to ceftriaxone, a worrying resistance to azithromycin and a wide variety of circulating sequence types have been detected, some of which show correlation with certain resistance profiles.
El aumento de las infecciones de transmisión sexual producidas por Neisseria gonorrhoeae (NG) a nivel mundial, junto con la disminución de la susceptibilidad antibiótica, obliga a profundizar en la epidemiologia de la infección gonocócica.
El proyecto GONOvig analizó, comparativamente siguiendo criterios CLSI y EUCAST, la sensibilidad antibiótica de 227 cepas de NG recogidas en trece hospitales representativos de la Comunidad Valencia (CV) entre los años 2013 y 2018. Adicionalmente, se pudo realizar la tipificación molecular de 175 cepas mediante la técnica NG multi-antigen sequence typing (NG-MAST).
Se detectaron elevadas tasas de resistencia a tetraciclina (38,2% por CLSI y 50,9% por EUCAST) y ciprofloxacino (49,1% CLSI y 54% EUCAST), y bajos porcentajes de resistencia a espectinomicina (0%), cefixima (0,5% CLSI pero 5,9% EUCAST) y ceftriaxona (1,5% CLSI y 2,4% EUCAST). La resistencia a azitromicina fue del 6% (tanto CLSI como EUCAST). El análisis molecular reveló la presencia de 86 secuenciotipos (ST) distintos, destacando el ST2992 (7,4%), ST3378 (6,9%), ST2400 (4,6%) y ST13288 (6,9%) el cual presentaba asociación con resistencia a cefixima (P=,031). Los genogrupos (G) mayoritarios fueron el G1407 (13,1%), G2992 (10,3%), G2400 (6,3%) y G387 (3,4%); G1407 y G2400 mostraron asociación con resistencia a ciprofloxacino (P<,03).
Se ha detectado una baja resistencia a ceftriaxona, una preocupante resistencia a azitromicina y una gran variedad de secuenciotipos circulantes, algunos de los cuales presentan correlación con determinados perfiles de resistencia. |
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AbstractList | INTRODUCTIONThe increase in sexually transmitted infections (STI) caused by Neisseria gonorrhoeae (NG) worldwide, together with the decrease in antibiotic susceptibility, forced us to understand the epidemiology of gonococcal infection.METHODSThe GONOvig project analyzed, comparatively following CLSI and EUCAST criteria, the antibiotic susceptibility of 227 NG strains collected in thirteen representative hospitals of the Valencia Community (CV) between 2013 and 2018. Additionally, molecular typing of 175 strains using the NG multi-antigen sequence typing technique (NG-MAST) was performed.RESULTSHigh rates of resistance to tetracycline (38.2% by CLSI and 50.9% by EUCAST) and ciprofloxacin (49.1% CLSI and 54% EUCAST), and low percentages of resistance to spectinomycin (0%), cefixime (0.5% CLSI but 5.9% EUCAST), and ceftriaxone (1.5% CLSI and 2.4% EUCAST) were detected. Azithromycin resistance was 6% (both CLSI and EUCAST). Molecular analysis revealed the presence of 86 different sequence types (ST), highlighting ST2992 (7.4%), ST3378 (6.9%), ST2400 (4.6%) and ST13288 (6.9%), which was associated with resistance to cefixime (P=.031). The main genogroups (G) were G1407 (13.1%), G2992 (10.3%), G2400 (6.3%) and G387 (3.4%). G1407 and G2400 were associated with resistance to ciprofloxacin (P<.03).CONCLUSIONLow resistance to ceftriaxone, a worrying resistance to azithromycin and a wide variety of circulating sequence types have been detected, some of which show correlation with certain resistance profiles. The increase in sexually transmitted infections (STI) caused by Neisseria gonorrhoeae (NG) worldwide, together with the decrease in antibiotic susceptibility, forced us to understand the epidemiology of gonococcal infection. The GONOvig project analyzed, comparatively following CLSI and EUCAST criteria, the antibiotic susceptibility of 227 NG strains collected in thirteen representative hospitals of the Valencia Community (CV) between 2013 and 2018. Additionally, molecular typing of 175 strains using the NG multi-antigen sequence typing technique (NG-MAST) was performed. High rates of resistance to tetracycline (38.2% by CLSI and 50.9% by EUCAST) and ciprofloxacin (49.1% CLSI and 54% EUCAST), and low percentages of resistance to spectinomycin (0%), cefixime (0.5% CLSI but 5.9% EUCAST), and ceftriaxone (1.5% CLSI and 2.4% EUCAST) were detected. Azithromycin resistance was 6% (both CLSI and EUCAST). Molecular analysis revealed the presence of 86 different sequence types (ST), highlighting ST2992 (7.4%), ST3378 (6.9%), ST2400 (4.6%) and ST13288 (6.9%), which was associated with resistance to cefixime (P=.031). The main genogroups (G) were G1407 (13.1%), G2992 (10.3%), G2400 (6.3%) and G387 (3.4%). G1407 and G2400 were associated with resistance to ciprofloxacin (P<.03). Low resistance to ceftriaxone, a worrying resistance to azithromycin and a wide variety of circulating sequence types have been detected, some of which show correlation with certain resistance profiles. El aumento de las infecciones de transmisión sexual producidas por Neisseria gonorrhoeae (NG) a nivel mundial, junto con la disminución de la susceptibilidad antibiótica, obliga a profundizar en la epidemiologia de la infección gonocócica. El proyecto GONOvig analizó, comparativamente siguiendo criterios CLSI y EUCAST, la sensibilidad antibiótica de 227 cepas de NG recogidas en trece hospitales representativos de la Comunidad Valencia (CV) entre los años 2013 y 2018. Adicionalmente, se pudo realizar la tipificación molecular de 175 cepas mediante la técnica NG multi-antigen sequence typing (NG-MAST). Se detectaron elevadas tasas de resistencia a tetraciclina (38,2% por CLSI y 50,9% por EUCAST) y ciprofloxacino (49,1% CLSI y 54% EUCAST), y bajos porcentajes de resistencia a espectinomicina (0%), cefixima (0,5% CLSI pero 5,9% EUCAST) y ceftriaxona (1,5% CLSI y 2,4% EUCAST). La resistencia a azitromicina fue del 6% (tanto CLSI como EUCAST). El análisis molecular reveló la presencia de 86 secuenciotipos (ST) distintos, destacando el ST2992 (7,4%), ST3378 (6,9%), ST2400 (4,6%) y ST13288 (6,9%) el cual presentaba asociación con resistencia a cefixima (P=,031). Los genogrupos (G) mayoritarios fueron el G1407 (13,1%), G2992 (10,3%), G2400 (6,3%) y G387 (3,4%); G1407 y G2400 mostraron asociación con resistencia a ciprofloxacino (P<,03). Se ha detectado una baja resistencia a ceftriaxona, una preocupante resistencia a azitromicina y una gran variedad de secuenciotipos circulantes, algunos de los cuales presentan correlación con determinados perfiles de resistencia. The increase in sexually transmitted infections (STI) caused by Neisseria gonorrhoeae (NG) worldwide, together with the decrease in antibiotic susceptibility, forced us to understand the epidemiology of gonococcal infection. The GONOvig project analyzed, comparatively following CLSI and EUCAST criteria, the antibiotic susceptibility of 227 NG strains collected in thirteen representative hospitals of the Valencia Community (CV) between 2013 and 2018. Additionally, molecular typing of 175 strains using the NG multi-antigen sequence typing technique (NG-MAST) was performed. High rates of resistance to tetracycline (38.2% by CLSI and 50.9% by EUCAST) and ciprofloxacin (49.1% CLSI and 54% EUCAST), and low percentages of resistance to spectinomycin (0%), cefixime (0.5% CLSI but 5.9% EUCAST), and ceftriaxone (1.5% CLSI and 2.4% EUCAST) were detected. Azithromycin resistance was 6% (both CLSI and EUCAST). Molecular analysis revealed the presence of 86 different sequence types (ST), highlighting ST2992 (7.4%), ST3378 (6.9%), ST2400 (4.6%) and ST13288 (6.9%), which was associated with resistance to cefixime (P=.031). The main genogroups (G) were G1407 (13.1%), G2992 (10.3%), G2400 (6.3%) and G387 (3.4%). G1407 and G2400 were associated with resistance to ciprofloxacin (P<.03). Low resistance to ceftriaxone, a worrying resistance to azithromycin and a wide variety of circulating sequence types have been detected, some of which show correlation with certain resistance profiles. |
Author | Bueno Ferrando, Felipe Fabregat Bolufer, Aleix Borja Colomina Rodríguez, Javier Navarro Ortega, David |
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Keywords | Bacterial Molecular typing Neisseria gonorrhoeae Bacteriano Drug resistance Resistencia antibiótica Caracterización molecular |
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References | European Centre for Disease Prevention and Control. Gonorrhoea: Annual Epidemiological Report for 2018 [accessed 4 Jul 2022]. Available from Cámara, Serra, Ayats, Bastida, Carnicer-Pont, Andreu (bib0140) 2012; 67 Rowley, Vander Hoorn, Korenromp, Low, Unemo, Abu-Raddad (bib0005) 2019; 97 World Health Organization (WHO). 2019 Antibacterial agents in clinical development: an analysis of the antibacterial clinical development pipeline [accessed 14 Jul 2022]. Available from Martin, Ison, Aanensen, Fenton, Spratt (bib0065) 2004; 189 European Centre for Disease Prevention and Control. Gonococcal antimicrobial susceptibility surveillance in Europe – Results summary 2017 [accessed 6 Jul 2022]. Available from The European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 10.0 [accessed 6 Jul 2022]. Available from Cobo, Cabezas-Fernández, Cabeza-Barrera (bib0105) 2016; 34 Castaño Aroca, Acosta Boga, Lozano Rodríguez, Chouman Arcas (bib0115) 2020; 38 European Centre for Disease Prevention and Control. Gonococcal antimicrobial susceptibility surveillance in Europe – Results summary 2018. 2020 [accessed 7 Jul 2022]. Available from Palmer, Young, Graham, Dave (bib0035) 2008; 84 Fifer, Saunders, Soni, Sadiq, FitzGerald (bib0025) 2020; 31 Chisholm, Unemo, Quaye, Johansson, Cole, Ison (bib0070) 2013; 18 World Health Organization. 2018 Report on global sexually transmitted infection surveillance [accessed 6 Jul 2022]. Available from 2019. Alirol, Wi, Bala, Bazzo, Chen, Deal (bib0150) 2017; 14 Bilek, Martin, Bell, Kinghorn, Ison, Spratt (bib0030) 2007; 45 2020. Unemo, Ross, Serwin, Gomberg, Cusini, Jensen (bib0020) 2020; 32 Ison, Hussey, Sankar, Evans, Alexander (bib0145) 2011; 16 Cobo, Cabezas-Fernández, Avivar (bib0110) 2019; 32 European Centre for Disease Prevention and Control. Molecular typing of Neisseria gonorrhoeae – a study of 2013 isolates. 2018 [accessed 7 Jul 2022]. Available from . Serra Pladevall J. Neisseria gonorrhoeae: monitorització de la sensibilitat antimicrobiana, estudi de la dinàmica poblacional i caracterització molecular de les resistències. 2016 [accessed 6 Jul 2022]. Available from Carannante, Vacca, Lo Presti, Stefanelli (bib0130) 2019; 32 St Cyr, Barbee, Workowski, Bachmann, Pham, Schlanger (bib0015) 2020; 69 Jennison, Whiley, Lahra, Graham, Cole, Hughes (bib0085) 2019; 24 Guo, Ye, Zhao, Ma, Yang, Luo (bib0050) 2014; 6 Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing. 30th ed. CLSI supplement M100. (ISBN 978-1-68440-066-9 [Print]; ISBN 978-1-68440-067-6 [Electronic]). Unemo, Golparian, Nicholas, Ohnishi, Gallay, Sednaoui (bib0135) 2012; 56 Jacobsson, Golparian, Cole, Spiteri, Martin, Bergheim (bib0075) 2016; 71 Serra-Pladevall, Barberá-Gracia, Roig-Carbajosa, Juvé-Saumell, Gonzalez-Lopez, Bartolomé-Comas (bib0095) 2013; 31 2018. Monfort, Caro, Devaux, Delannoy, Brisse, Sednaoui (bib0040) 2009; 47 10.1016/j.eimce.2022.08.009_bib0060 Guo (10.1016/j.eimce.2022.08.009_bib0050) 2014; 6 10.1016/j.eimce.2022.08.009_bib0080 10.1016/j.eimce.2022.08.009_bib0120 Cobo (10.1016/j.eimce.2022.08.009_bib0110) 2019; 32 Castaño Aroca (10.1016/j.eimce.2022.08.009_bib0115) 2020; 38 St Cyr (10.1016/j.eimce.2022.08.009_bib0015) 2020; 69 10.1016/j.eimce.2022.08.009_bib0045 10.1016/j.eimce.2022.08.009_bib0100 Rowley (10.1016/j.eimce.2022.08.009_bib0005) 2019; 97 Monfort (10.1016/j.eimce.2022.08.009_bib0040) 2009; 47 Chisholm (10.1016/j.eimce.2022.08.009_bib0070) 2013; 18 Jacobsson (10.1016/j.eimce.2022.08.009_bib0075) 2016; 71 Unemo (10.1016/j.eimce.2022.08.009_bib0020) 2020; 32 Jennison (10.1016/j.eimce.2022.08.009_bib0085) 2019; 24 Martin (10.1016/j.eimce.2022.08.009_bib0065) 2004; 189 Carannante (10.1016/j.eimce.2022.08.009_bib0130) 2019; 32 10.1016/j.eimce.2022.08.009_bib0090 Ison (10.1016/j.eimce.2022.08.009_bib0145) 2011; 16 Serra-Pladevall (10.1016/j.eimce.2022.08.009_bib0095) 2013; 31 10.1016/j.eimce.2022.08.009_bib0010 Fifer (10.1016/j.eimce.2022.08.009_bib0025) 2020; 31 Alirol (10.1016/j.eimce.2022.08.009_bib0150) 2017; 14 10.1016/j.eimce.2022.08.009_bib0055 Bilek (10.1016/j.eimce.2022.08.009_bib0030) 2007; 45 Palmer (10.1016/j.eimce.2022.08.009_bib0035) 2008; 84 Cobo (10.1016/j.eimce.2022.08.009_bib0105) 2016; 34 10.1016/j.eimce.2022.08.009_bib0125 Cámara (10.1016/j.eimce.2022.08.009_bib0140) 2012; 67 Unemo (10.1016/j.eimce.2022.08.009_bib0135) 2012; 56 |
References_xml | – volume: 6 start-page: 534 year: 2014 end-page: 538 ident: bib0050 article-title: Comparative study of MALDI-TOF MS and VITEK 2 in bacteria identification publication-title: J Thorac Dis. contributor: fullname: Luo – volume: 16 year: 2011 ident: bib0145 article-title: Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010 publication-title: Eurosurveillance. contributor: fullname: Alexander – volume: 38 start-page: 348 year: 2020 end-page: 349 ident: bib0115 article-title: Antimicrobial susceptibility study of Neisseria gonorrhoeae in the health area of the University and Polytechnic La Fe Hospital of Valencia publication-title: Enferm Infecc Microbiol Clin. contributor: fullname: Chouman Arcas – volume: 71 start-page: 3109 year: 2016 end-page: 3116 ident: bib0075 article-title: WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC &2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014 publication-title: J Antimicrob Chemother. contributor: fullname: Bergheim – volume: 84 start-page: 280 year: 2008 end-page: 284 ident: bib0035 article-title: Prediction of antibiotic resistance using Neisseria gonorrhoeae multi-antigen sequence typing publication-title: Sex Transm Infect. contributor: fullname: Dave – volume: 69 start-page: 1911 year: 2020 end-page: 1916 ident: bib0015 article-title: Update to CDC’s Treatment Guidelines for Gonococcal Infection, 2020 publication-title: MMWR Morb Mortal Wkly Rep. contributor: fullname: Schlanger – volume: 34 start-page: 3 year: 2016 end-page: 7 ident: bib0105 article-title: Antimicrobial susceptibility and typing of Neisseria gonorrhoeae strains from Southern Spain, 2012-2014 publication-title: Enferm Infecc Microbiol Clin. contributor: fullname: Cabeza-Barrera – volume: 97 start-page: 548 year: 2019 end-page: 562 ident: bib0005 article-title: Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016 publication-title: Bull World Health Organ. contributor: fullname: Abu-Raddad – volume: 24 start-page: 1 year: 2019 end-page: 4 ident: bib0085 article-title: Genetic relatedness of ceftriaxone-resistant and high-level azithromycin resistant Neisseria gonorrhoeae cases, United Kingdom and Australia, February to April 2018 publication-title: Eurosurveillance. contributor: fullname: Hughes – volume: 32 start-page: 8 year: 2019 end-page: 15 ident: bib0130 article-title: Sorveglianza di laboratorio del l’antibiotico-resistenza in Neisseria gonorrhoeae: risultati del biennio 2016-2017 publication-title: Not Ist Super Sanità. contributor: fullname: Stefanelli – volume: 56 start-page: 1273 year: 2012 end-page: 1280 ident: bib0135 article-title: High-level cefixime and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure publication-title: Antimicrob Agents Chemother. contributor: fullname: Sednaoui – volume: 32 start-page: 1018 year: 2020 end-page: 1026 ident: bib0020 article-title: 2020 European guideline for the diagnosis and treatment of gonorrhoea in adults publication-title: Int J STD AIDS. contributor: fullname: Jensen – volume: 67 start-page: 1858 year: 2012 end-page: 1860 ident: bib0140 article-title: Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain publication-title: J Antimicrob Chemother. contributor: fullname: Andreu – volume: 45 start-page: 3564 year: 2007 end-page: 3567 ident: bib0030 article-title: Concordance between Neisseria gonorrhoeae genotypes recovered from known sexual contacts publication-title: J Clin Microbiol. contributor: fullname: Spratt – volume: 47 start-page: 3540 year: 2009 end-page: 3545 ident: bib0040 article-title: First Neisseria gonorrhoeae genotyping analysis in France: identification of a strain cluster with reduced susceptibility to ceftriaxone publication-title: J Clin Microbiol. contributor: fullname: Sednaoui – volume: 31 start-page: 579 year: 2013 end-page: 583 ident: bib0095 article-title: Neisseria gonorrhoeae: antimicrobial resistance and study of population dynamics. Situation in Barcelona in 2011 publication-title: Enferm Infecc Microbiol Clin. contributor: fullname: Bartolomé-Comas – volume: 31 start-page: 4 year: 2020 end-page: 15 ident: bib0025 article-title: 2018 UK national guideline for the management of infection with Neisseria gonorrhoeae publication-title: Int J STD AIDS. contributor: fullname: FitzGerald – volume: 18 start-page: 20358 year: 2013 ident: bib0070 article-title: Molecular epidemiological typing within the European Gonococcal Antimicrobial Resistance Surveillance Programme reveals predominance of a multidrug-resistant clone publication-title: Eurosurveillance. contributor: fullname: Ison – volume: 32 start-page: 114 year: 2019 end-page: 120 ident: bib0110 article-title: Typing and antimicrobial susceptibility of 134 Neisseria gonorrhoeae strains from Southern Spain publication-title: Rev Esp Quimioter. contributor: fullname: Avivar – volume: 14 year: 2017 ident: bib0150 article-title: Multidrug-resistant gonorrhea: a research and development roadmap to discover new medicines publication-title: PLoS Med. contributor: fullname: Deal – volume: 189 start-page: 1497 year: 2004 end-page: 1505 ident: bib0065 article-title: Rapid sequence‐based identification of gonococcal transmission clusters in a large metropolitan area publication-title: J Infect Dis. contributor: fullname: Spratt – volume: 189 start-page: 1497 year: 2004 ident: 10.1016/j.eimce.2022.08.009_bib0065 article-title: Rapid sequence‐based identification of gonococcal transmission clusters in a large metropolitan area publication-title: J Infect Dis. doi: 10.1086/383047 contributor: fullname: Martin – volume: 31 start-page: 579 year: 2013 ident: 10.1016/j.eimce.2022.08.009_bib0095 article-title: Neisseria gonorrhoeae: antimicrobial resistance and study of population dynamics. Situation in Barcelona in 2011 publication-title: Enferm Infecc Microbiol Clin. doi: 10.1016/j.eimc.2013.03.010 contributor: fullname: Serra-Pladevall – volume: 14 year: 2017 ident: 10.1016/j.eimce.2022.08.009_bib0150 article-title: Multidrug-resistant gonorrhea: a research and development roadmap to discover new medicines publication-title: PLoS Med. doi: 10.1371/journal.pmed.1002366 contributor: fullname: Alirol – volume: 6 start-page: 534 year: 2014 ident: 10.1016/j.eimce.2022.08.009_bib0050 article-title: Comparative study of MALDI-TOF MS and VITEK 2 in bacteria identification publication-title: J Thorac Dis. contributor: fullname: Guo – volume: 24 start-page: 1 year: 2019 ident: 10.1016/j.eimce.2022.08.009_bib0085 article-title: Genetic relatedness of ceftriaxone-resistant and high-level azithromycin resistant Neisseria gonorrhoeae cases, United Kingdom and Australia, February to April 2018 publication-title: Eurosurveillance. doi: 10.2807/1560-7917.ES.2019.24.8.1900118 contributor: fullname: Jennison – volume: 32 start-page: 1018 year: 2020 ident: 10.1016/j.eimce.2022.08.009_bib0020 article-title: 2020 European guideline for the diagnosis and treatment of gonorrhoea in adults publication-title: Int J STD AIDS. contributor: fullname: Unemo – ident: 10.1016/j.eimce.2022.08.009_bib0120 – volume: 69 start-page: 1911 year: 2020 ident: 10.1016/j.eimce.2022.08.009_bib0015 article-title: Update to CDC’s Treatment Guidelines for Gonococcal Infection, 2020 publication-title: MMWR Morb Mortal Wkly Rep. doi: 10.15585/mmwr.mm6950a6 contributor: fullname: St Cyr – volume: 56 start-page: 1273 year: 2012 ident: 10.1016/j.eimce.2022.08.009_bib0135 article-title: High-level cefixime and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure publication-title: Antimicrob Agents Chemother. doi: 10.1128/AAC.05760-11 contributor: fullname: Unemo – volume: 18 start-page: 20358 year: 2013 ident: 10.1016/j.eimce.2022.08.009_bib0070 article-title: Molecular epidemiological typing within the European Gonococcal Antimicrobial Resistance Surveillance Programme reveals predominance of a multidrug-resistant clone publication-title: Eurosurveillance. doi: 10.2807/ese.18.03.20358-en contributor: fullname: Chisholm – volume: 34 start-page: 3 year: 2016 ident: 10.1016/j.eimce.2022.08.009_bib0105 article-title: Antimicrobial susceptibility and typing of Neisseria gonorrhoeae strains from Southern Spain, 2012-2014 publication-title: Enferm Infecc Microbiol Clin. doi: 10.1016/j.eimc.2015.01.017 contributor: fullname: Cobo – ident: 10.1016/j.eimce.2022.08.009_bib0055 – volume: 97 start-page: 548 year: 2019 ident: 10.1016/j.eimce.2022.08.009_bib0005 article-title: Chlamydia, gonorrhoea, trichomoniasis and syphilis: global prevalence and incidence estimates, 2016 publication-title: Bull World Health Organ. doi: 10.2471/BLT.18.228486 contributor: fullname: Rowley – volume: 38 start-page: 348 year: 2020 ident: 10.1016/j.eimce.2022.08.009_bib0115 article-title: Antimicrobial susceptibility study of Neisseria gonorrhoeae in the health area of the University and Polytechnic La Fe Hospital of Valencia publication-title: Enferm Infecc Microbiol Clin. doi: 10.1016/j.eimc.2019.12.002 contributor: fullname: Castaño Aroca – volume: 67 start-page: 1858 year: 2012 ident: 10.1016/j.eimce.2022.08.009_bib0140 article-title: Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain publication-title: J Antimicrob Chemother. doi: 10.1093/jac/dks162 contributor: fullname: Cámara – ident: 10.1016/j.eimce.2022.08.009_bib0080 – ident: 10.1016/j.eimce.2022.08.009_bib0045 – volume: 16 year: 2011 ident: 10.1016/j.eimce.2022.08.009_bib0145 article-title: Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010 publication-title: Eurosurveillance. doi: 10.2807/ese.16.14.19833-en contributor: fullname: Ison – ident: 10.1016/j.eimce.2022.08.009_bib0060 – ident: 10.1016/j.eimce.2022.08.009_bib0010 – volume: 71 start-page: 3109 year: 2016 ident: 10.1016/j.eimce.2022.08.009_bib0075 article-title: WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC &2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014 publication-title: J Antimicrob Chemother. doi: 10.1093/jac/dkw279 contributor: fullname: Jacobsson – volume: 32 start-page: 8 year: 2019 ident: 10.1016/j.eimce.2022.08.009_bib0130 article-title: Sorveglianza di laboratorio del l’antibiotico-resistenza in Neisseria gonorrhoeae: risultati del biennio 2016-2017 publication-title: Not Ist Super Sanità. contributor: fullname: Carannante – volume: 45 start-page: 3564 year: 2007 ident: 10.1016/j.eimce.2022.08.009_bib0030 article-title: Concordance between Neisseria gonorrhoeae genotypes recovered from known sexual contacts publication-title: J Clin Microbiol. doi: 10.1128/JCM.01453-07 contributor: fullname: Bilek – volume: 32 start-page: 114 year: 2019 ident: 10.1016/j.eimce.2022.08.009_bib0110 article-title: Typing and antimicrobial susceptibility of 134 Neisseria gonorrhoeae strains from Southern Spain publication-title: Rev Esp Quimioter. contributor: fullname: Cobo – ident: 10.1016/j.eimce.2022.08.009_bib0100 – volume: 84 start-page: 280 year: 2008 ident: 10.1016/j.eimce.2022.08.009_bib0035 article-title: Prediction of antibiotic resistance using Neisseria gonorrhoeae multi-antigen sequence typing publication-title: Sex Transm Infect. doi: 10.1136/sti.2008.029694 contributor: fullname: Palmer – volume: 47 start-page: 3540 year: 2009 ident: 10.1016/j.eimce.2022.08.009_bib0040 article-title: First Neisseria gonorrhoeae genotyping analysis in France: identification of a strain cluster with reduced susceptibility to ceftriaxone publication-title: J Clin Microbiol. doi: 10.1128/JCM.01236-09 contributor: fullname: Monfort – ident: 10.1016/j.eimce.2022.08.009_bib0090 – ident: 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Snippet | The increase in sexually transmitted infections (STI) caused by Neisseria gonorrhoeae (NG) worldwide, together with the decrease in antibiotic susceptibility,... INTRODUCTIONThe increase in sexually transmitted infections (STI) caused by Neisseria gonorrhoeae (NG) worldwide, together with the decrease in antibiotic... |
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SubjectTerms | Anti-Bacterial Agents - pharmacology Azithromycin Bacterial Bacteriano Caracterización molecular Cefixime - pharmacology Ceftriaxone - pharmacology Ciprofloxacin - pharmacology Drug resistance Genotype Gonorrhea - epidemiology Humans Microbial Sensitivity Tests Molecular typing Neisseria gonorrhoeae Neisseria gonorrhoeae - genetics Resistencia antibiótica Spain - epidemiology |
Title | Antibiotic susceptibility and genotypic characterization of Neisseria gonorrhoeae isolates in the Comunidad Valenciana (Spain): GONOvig project |
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