Stable Isotope Labelling Kinetics: Models and methods to evaluate APP production rates with Posiphen treatment in the DISCOVER clinical trial

• Published in: Alzheimer's & dementia Vol. 19; no. S21
• Main Authors: Elbert, Donald L, Galasko, Douglas R., Farlow, Martin R., Aslanyan, Vahan, Pa, Judy, Lucey, Brendan, Honig, Lawrence S., Moghekar, Abhay, Bateman, Randall J., Momper, Jeremiah, Rissman, Robert A, Balasubramanian, Archana, Maccecchini, Maria L., Feldman, Howard H.
• Format: Journal Article
• Language: English
• Published: 01.12.2023

Background Posiphen has been reported to decrease translation of beta amyloid precursor protein (APP) mRNA, resulting in decreased production of Aβ.1 The pharmacodynamics of Posiphen require further clarification to better assess its therapeutic potential. Method The DISCOVER phase 1b placebo contro...