Paragangliomas of the head and neck region show complete loss of heterozygosity at 11 q22-q23 in chief cells and the flow-sorted dna aneuploid fraction

• Published in: Human pathology Vol. 29; no. 10; pp. 1045 - 1049
• Main Authors: Van Schothorst, Evert M., Beekman, Marian, Torremans, Petra, Kuipers-Dijkshoorn, Nel J., Wessels, Hans W., Bardoel, Alfons F.J., Van Der Mey, Andel G.L., Van Der Vijver, Marc J., Van Ommen, Gert-Jan B., Devilee, Peter, Cornelisse, Cees J.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.10.1998
• Subjects: aneuploid fraction; chief cell; LOH; paraganglioma; PGL1; LOH; HN-paraganglioma; aneuploid fraction; chief cell; PGL1; EDTA; PCR; AIF; paraganglioma

Nonchromaffin paragangliomas of the head and neck region, also known as glomus tumors, are usually benign neoplasms consisting of clusters of chief cells surrounded by sustentacular cells arranged in so-called ‘Zellballen’. Most of the patients have a familial background. In a previous study, examin...