TLR4- and TLR9-dependent effects on cytokines, cell viability, and invasion in human bladder cancer cells1These authors contributed equally to this work

• Published in: Urologic oncology Vol. 33; no. 3; pp. 110.e19 - 110.e27
• Main Authors: Olbert, Peter J., Kesch, Claudia, Henrici, Marcus, Subtil, Florentine S., Honacker, Astrid, Hegele, Axel, Hofmann, Rainer, Hänze, Jörg
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.03.2015
• Subjects: Bladder cancer; Cell viability; Immunotherapy; Invasion; TLR4; TLR9; TLR9; Cell viability; Bladder cancer; TLR4; Immunotherapy; Invasion

Adjuvant immunotherapy of bladder cancer by instillation of bacillus Calmette-Guérin (BCG) is highly recommended within certain groups of non–muscle-invasive stages but only partially effective. Toll-like receptors (TLRs) TLR4 and TLR9 likely mediate BCG effects by triggering innate systemic immune...