Leukemia Stem Cells Are Characterized By CLEC12A Expression and Chemotherapy Refractoriness That Can be Overcome By Targeting with Chimeric Antigen Receptor T Cells

• Published in: Blood Vol. 128; no. 22; p. 766
• Main Authors: Kenderian, Saad S, Ruella, Marco, Shestova, Olga, Klichinsky, Michael, Kim, Miriam Y, Soderquist, Craig, Bagg, Adam, Singh, Reshma, Richardson, Celeste, Young, Regina M, June, Carl H, Gill, Saar I.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 02.12.2016

Chemo-refractory acute myeloid leukemia (AML) is associated with poor prognosis and treatment options are extremely limited. Most of these patients are ineligible for allogeneic stem cell transplantation. Chemo-refractory AML is thought to arise due to selection pressure of resistant clones from pri...