Heme Induced Spinal Microglial Cell Activation By TLR4 and Endoplasmic Reticulum Stress in Sickle Mice

• Published in: Blood Vol. 124; no. 21; p. 452
• Main Authors: Paul, Jinny, Lei, Jianxun, Jha, Ritu, Nguyen, Julia, Simone, Donald A, Gupta, Kalpna
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 06.12.2014

Sickle cell disease (SCD) is associated with pain, which remains a major challenge to treat. Earlier, we showed that peripheral mechanisms including mast cell activation in the skin contribute to pain in sickle mice (Vincent et al., Blood 2013). Mast cell activation in sickle mice was accompanied by...