An Fc-Engineered Humanized Anti-CD40 Monoclonal Antibody, XmAb5485, Exhibits Potent Activity in Vitro and in Vivo against Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia and Multiple Myeloma

• Published in: Blood Vol. 112; no. 11; p. 881
• Main Authors: Zhukovsky, Eugene A., Horton, Holly, Peipp, Matthias, Pong, Erik, Bernett, Matthew, Karki, Sher, Richards, John, Chu, Seung, Repp, Roland, Desjarlais, John
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 16.11.2008

CD40, a transmembrane glycoprotein belonging to the tumor necrosis factor receptor family, is an attractive target for cancers of lymphoid origin since it is expressed on most mature B-cell malignancies, some early B-cell acute lymphocytic leukemias, and multiple myeloma. Finding efficient therapies...