Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches

• Published in: Chemical communications (Cambridge, England)
• Main Authors: Giannessi, Lisa, Longo, Matteo, Massera, Chiara, Radi, Marco
• Format: Journal Article
• Language: English
• Published: 14.08.2024

We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype. Using the recently discovered PCSK9 inhibitor 5c as a prototype, a series of electrochemical LSF (e-LSF) and multicomponent LSF (MCR...