Late-stage functionalization of the 4-amino-2-pyridone chemotype using electrochemical and MCR approaches

We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype. Using the recently discovered PCSK9 inhibitor 5c as a prototype, a series of electrochemical LSF (e-LSF) and multicomponent LSF (MCR...

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Bibliographic Details
Published inChemical communications (Cambridge, England)
Main Authors Giannessi, Lisa, Longo, Matteo, Massera, Chiara, Radi, Marco
Format Journal Article
LanguageEnglish
Published 14.08.2024
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Summary:We report the development and application of different strategies for the late-stage functionalization (LSF) of the biologically relevant 4-amino-2-pyridone chemotype. Using the recently discovered PCSK9 inhibitor 5c as a prototype, a series of electrochemical LSF (e-LSF) and multicomponent LSF (MCR-LSF) have been set-up to decorate the 4-amino-2-pyridone scaffold. The usefulness of these methods has been demonstrated by generating a series of novel derivatives in a site-selective and sustainable way.
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/D4CC02473G