Progress in immunoregulatory mechanisms during distraction osteogenesis

• Published in: Frontiers in bioengineering and biotechnology Vol. 13
• Main Authors: Huang, Shiyu, Zeng, Aoran, Yin, Qing, Yang, Qiming, Zou, Bing, He, Meiying, Wang, Juehan, Pan, Qi
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 25.08.2025
• Subjects: biomaterials; bone regeneration; cytokines; distraction osteogenesis; immunomodulation

Distraction osteogenesis (DO) is an endogenous bone tissue engineering technique that harnesses the regenerative potential of bone and has been widely applied in limb lengthening, bone defect repair, and craniofacial reconstruction. The DO procedure consists of three distinct phases: the latency pha...