Stage-resolved transcriptomic profiling of Anastrepha ludens (Diptera: Tephritidae) from egg to adult: molecular signatures of a notorious polyphagous fruit-fly pest

This study explores the transcriptional dynamics of the polyphagous Mexican Fruit Fly, Anastrepha ludens , across five developmental stages, revealing distinct gene expression patterns unique to each stage. We identified 9,762 DEGs associated with the four developmental stages. During the egg stage,...

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Published inFrontiers in insect science Vol. 5
Main Authors Cerqueda-García, Daniel, Osorio-Paz, Ixchel, Carpinteyro-Ponce, Javier, Ibarra-Laclette, Enrique, Altúzar-Molina, Alma, Aluja, Martín
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 29.08.2025
Subjects
Anastrepha ludens (Diptera: Tephritidae)
gene expression patterns
metabolic pathways
transcriptional dynamics
transcriptomic profiling
Online AccessGet full text
ISSN2673-8600
2673-8600
DOI10.3389/finsc.2025.1618382

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Abstract This study explores the transcriptional dynamics of the polyphagous Mexican Fruit Fly, Anastrepha ludens , across five developmental stages, revealing distinct gene expression patterns unique to each stage. We identified 9,762 DEGs associated with the four developmental stages. During the egg stage, we identified the greatest number of differentially expressed genes exhibiting a pronounced activity of metabolic pathways, particularly the Mitogen-Associated Protein Kinase (MAPK) signaling pathway, which is essential for embryonic development and defense mechanisms. The second larval instar stage mainly focused on growth, as shown by the overexpression of the Transforming Growth Factor Beta (TGF-beta) pathway. In the third larval stage, genes are significantly enriched in cuticle structure and transmembrane transport. In the pupal stage, the importance of the TGF-beta and mTOR pathways emerged, vital for tissue homeostasis and development. The adult stage exhibited sustained expression of the FOXO pathway, enhancing stress resistance crucial for survival and reproduction. Additionally, we noted differences in odor-binding protein (OBP) expression between sexes, hinting at their potential role in mating behavior. These findings provide fundamental information about the life stages of A. ludens , highlighting the importance of specific signaling pathways and OBPs, which could help improve mass rearing processes and management strategies for this notorious tephritid pest.
AbstractList This study explores the transcriptional dynamics of the polyphagous Mexican Fruit Fly, Anastrepha ludens, across five developmental stages, revealing distinct gene expression patterns unique to each stage. We identified 9,762 DEGs associated with the four developmental stages. During the egg stage, we identified the greatest number of differentially expressed genes exhibiting a pronounced activity of metabolic pathways, particularly the Mitogen-Associated Protein Kinase (MAPK) signaling pathway, which is essential for embryonic development and defense mechanisms. The second larval instar stage mainly focused on growth, as shown by the overexpression of the Transforming Growth Factor Beta (TGF-beta) pathway. In the third larval stage, genes are significantly enriched in cuticle structure and transmembrane transport. In the pupal stage, the importance of the TGF-beta and mTOR pathways emerged, vital for tissue homeostasis and development. The adult stage exhibited sustained expression of the FOXO pathway, enhancing stress resistance crucial for survival and reproduction. Additionally, we noted differences in odor-binding protein (OBP) expression between sexes, hinting at their potential role in mating behavior. These findings provide fundamental information about the life stages of A. ludens, highlighting the importance of specific signaling pathways and OBPs, which could help improve mass rearing processes and management strategies for this notorious tephritid pest.
Author Osorio-Paz, Ixchel
Cerqueda-García, Daniel
Ibarra-Laclette, Enrique
Aluja, Martín
Altúzar-Molina, Alma
Carpinteyro-Ponce, Javier
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Snippet This study explores the transcriptional dynamics of the polyphagous Mexican Fruit Fly, Anastrepha ludens , across five developmental stages, revealing distinct...
This study explores the transcriptional dynamics of the polyphagous Mexican Fruit Fly, Anastrepha ludens, across five developmental stages, revealing distinct...
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SubjectTerms Anastrepha ludens (Diptera: Tephritidae)
gene expression patterns
metabolic pathways
transcriptional dynamics
transcriptomic profiling
Title Stage-resolved transcriptomic profiling of Anastrepha ludens (Diptera: Tephritidae) from egg to adult: molecular signatures of a notorious polyphagous fruit-fly pest
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