Evaluation of Selected Renal Markers in Prostate Cancer

• Published in: Journal of Applied Sciences and Environmental Management Vol. 23; no. 9; p. 1725
• Main Authors: Oluboyo, A.O., Adeleke, A.T., Oluboyo, B.O.
• Format: Journal Article
• Language: English
• Published: Joint Coordination Centre of the World Bank assisted National Agricultural Research Programme (NARP) 21.10.2019
• Subjects: creatinine; cystatin C; Prostate cancer; urea
• ISSN: 1119-8362; 2659-1502; 2659-1499
• DOI: 10.4314/jasem.v23i9.18

Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer mortality. The study aimed to assess the level of urea, creatinine and cystatin C in prostate cancer subjects. The subjects consisted of 92 adult males between the ages of 45 to 70 years; 46 prostate cancer subjects and 46 apparently healthy subjects recruited from a Teaching Hospital in Nigeria. Urea and creatinine were estimated by colorimetric method, cystatin C was estimated using Enzyme linked immunosorbent assay (ELISA) technique. The results obtained showed that urea and creatinine were significantly high (p<0.05) while cystatin C was significantly low (p<0.05) in prostate cancer subjects compared with control subjects. Cystatin C was significantly high (p<0.05) in prostate cancer subjects on treatment compared with subjects not on treatment but there was no significant difference (p>0.05) in the levels of urea and creatinine. The research concluded that increased serum urea and creatinine concentrations as well as decreased cystatin C level may pose higher risk of renal dysfunction in prostate cancer subjects. Thus, the levels of serum urea, creatinine and cystatin C need to be evaluated in prostate cancer subjects. Keywords: Prostate cancer, cystatin C, urea, creatinine