Arrhythmogenic late Ca 2+ sparks in failing heart cells and their control by action potential configuration

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 5; pp. 2687 - 2692
• Main Authors: Fowler, Ewan D, Wang, Nan, Hezzell, Melanie, Chanoit, Guillaume, Hancox, Jules C, Cannell, Mark B
• Format: Journal Article
• Language: English
• Published: United States 04.02.2020
• Subjects: Action Potentials; Animals; Arrhythmias, Cardiac - metabolism; Arrhythmias, Cardiac - physiopathology; Calcium - metabolism; Excitation Contraction Coupling; Heart Failure - metabolism; Heart Failure - physiopathology; Humans; Myocytes, Cardiac - metabolism; cardiac myocytes; Ca2+ sparks; action potential; arrhythmia; heart

Sudden death in heart failure patients is a major clinical problem worldwide, but it is unclear how arrhythmogenic early afterdepolarizations (EADs) are triggered in failing heart cells. To examine EAD initiation, high-sensitivity intracellular Ca measurements were combined with action potential vol...