Increase in Tau Pathology in P290S Mapt Knock-In Mice Crossed with App NL-G-F Mice

• Published in: eNeuro Vol. 9; no. 6; p. ENEURO.0247-22.2022
• Main Authors: Huang, Melissa, Macdonald, Jennifer, Lavenir, Isabelle, Chen, Renren, Craxton, Molly, Slavik-Smith, Elizabeth, Davies, Stephen W., Goedert, Michel
• Format: Journal Article
• Language: English
• Published: United States 01.11.2022
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Animals; Brain - metabolism; Disease Models, Animal; Mice; Mice, Transgenic; Plaque, Amyloid - pathology; tau Proteins - genetics; tau Proteins - metabolism; amyloid-β; tau; Alzheimer’s disease; mouse model; knock-in

Alzheimer’s Disease (AD) is characterized by the pathologic assembly of amyloid β (Aβ) peptide, which deposits into extracellular plaques, and tau, which accumulates in intraneuronal inclusions. To investigate the link between Aβ and tau pathologies, experimental models featuring both pathologies ar...