Lower HER‐2/chromosome enumeration probe 17 ratio in cytologic HER‐2 fluorescence in situ hybridization for breast cancers

• Published in: Cancer Vol. 114; no. 2; pp. 134 - 140
• Main Authors: Itoh, Hitoshi, Miyajima, Yoko, Umemura, Shinobu, Osamura, Robert Y.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 25.04.2008
• Subjects: cytology; fluorescence in situ hybridization; HER‐2; paraffin‐embedded sections

BACKGROUND Fluorescence in situ hybridization (FISH) is the gold standard for assessing HER‐2 status for breast cancers, and paraffin‐embedded tissue sections are used routinely for HER‐2 FISH. Cytologic samples also are used, but to the authors' knowledge, little is known regarding the reliabi...