Quantitative proteomics reveals the mechanism of endoplasmic reticulum stress-mediated pulmonary fibrosis in mice

• Published in: Heliyon Vol. 10; no. 20; p. e39150
• Main Authors: Li, Heng, Wang, Jin, Li, Ziling, Wu, Zhidong, Zhang, Yan, Kong, Lingjia, Yang, Qingqing, Wang, Dong, Shi, He, Shen, Guozheng, Zou, Shuang, Zhu, Wenqing, Fan, Kaiyuan, Xu, Zhongwei
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 30.10.2024
• Subjects: Alveolar epithelial cell; Endoplasmic reticulum-stress; Fibrosis; TGF-β; Unfolded protein response; Alveolar epithelial cell; TGF-β; Endoplasmic reticulum-stress; Fibrosis; Unfolded protein response

Pulmonary fibrosis is a progressive disease that can lead to respiratory failure. Many types of cells are involved in the progression of pulmonary fibrosis. This study utilized quantitative proteomics to investigate the mechanism of TGF-β-induced fibrosis-like changes in mouse epithelial cells. Our...