Synthesis and Preclinical Evaluation of Urea-Based Prostate-Specific Membrane Antigen-Targeted Conjugates Labeled with 177 Lu

• Published in: ACS pharmacology & translational science Vol. 7; no. 5; pp. 1457 - 1473
• Main Authors: Machulkin, Aleksei E., Petrov, Stanislav A., Bodenko, Vitalina, Larkina, Mariia S., Plotnikov, Evgenii, Yuldasheva, Feruza, Tretyakova, Maria, Bezverkhniaia, Ekaterina, Zyk, Nikolay Yu, Stasyuk, Elena, Zelchan, Roman, Majouga, Alexander G., Tolmachev, Vladimir, Orlova, Anna, Beloglazkina, Elena K., Yusubov, Mekhman S.
• Format: Journal Article
• Language: English
• Published: United States 10.05.2024
• Subjects: DOTA; prostate cancer; prostate-specificmembrane antigen; PSMA; radiopharmaceuticals; targeted delivery

Lu-labeled small-molecule prostate-specific membrane antigen (PSMA) targeted tracers are therapeutic agents for metastatic castration-resistant prostate cancer. Optimizing molecular design holds the potential to further enhance the pharmacokinetic properties of PSMA-targeted agents while preserving...