Fusobacterium nucleatum infection induces CSF3 expression through p38 MAPK and JNK signaling pathways in oral squamous cell carcinoma cells

Oral bacterial infections substantially affect the development of various periodontal diseases and oral cancers. However, the molecular mechanisms underlying the association between Fusobacterium nucleatum (F. nucleatum ), a major periodontitis (PT)-associated pathogen, and these diseases require ex...

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Bibliographic Details
Published inInternational journal of oral biology Vol. 49; no. 1; pp. 1 - 9
Main Authors Jo, Ahyoung, Oh, Jung-Min
Format Journal Article
LanguageEnglish
Published 대한구강생물학회 31.03.2024
Subjects
치의학
p38 mitogen-activated protein kinases
CSF3
Fusobacterium nucleatum
JNK
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Table of Contents:
  • Introduction Materials and Methods 1. Cell culture 2. F usobacterium nucleatum culture and infection intoOSCC cells 3. RNA extraction and reverse transcriptionquantitativepolymerase chain reaction 4. Western blot analysis 5. Inhibitor treatment 6. Statistical analysis Results 1. F usobacterium nucleatum infection increases CSF3expression in OSCC cells 2. F usobacterium nucleatum infection inducesphosphorylation of AKT, p38 MAPK, and JNK inOSC-20 cells 3. The p38 MAPK and JNK signaling pathwaysregulate F. nucleatum -induced CSF3 expression inOSC-20 cells Discussion Funding Conflicts of Interest Supplementary Data References