Personalized translational epilepsy research — Novel approaches and future perspectives

• Published in: Epilepsy & behavior Vol. 76; pp. 7 - 12
• Main Authors: Bauer, Sebastian, van Alphen, Natascha, Becker, Albert, Chiocchetti, Andreas, Deichmann, Ralf, Deller, Thomas, Freiman, Thomas, Freitag, Christine M., Gehrig, Johannes, Hermsen, Anke M., Jedlicka, Peter, Kell, Christian, Klein, Karl Martin, Knake, Susanne, Kullmann, Dimitri M., Liebner, Stefan, Norwood, Braxton A., Omigie, Diana, Plate, Karlheinz, Reif, Andreas, Reif, Philipp S., Reiss, Yvonne, Roeper, Jochen, Ronellenfitsch, Michael W., Schorge, Stephanie, Schratt, Gerhard, Schwarzacher, Stephan W., Steinbach, Joachim P., Strzelczyk, Adam, Triesch, Jochen, Wagner, Marlies, Walker, Matthew C., von Wegner, Frederic, Rosenow, Felix
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.11.2017
• Subjects: Biomarkers; New treatment targets; Personalized medicine; Precision medicine; Treatment targets; Biomarkers; Precision medicine; New treatment targets; Personalized medicine; Treatment targets

Despite the availability of more than 15 new “antiepileptic drugs”, the proportion of patients with pharmacoresistant epilepsy has remained constant at about 20–30%. Furthermore, no disease-modifying treatments shown to prevent the development of epilepsy following an initial precipitating brain inj...