Interaction of Nectin with Afadin Is Necessary for Its Clustering at Cell-Cell Contact Sites but Not for Itscis Dimerization or trans Interaction

• Published in: The Journal of biological chemistry Vol. 275; no. 1; pp. 613 - 618
• Main Authors: Miyahara, Masako, Nakanishi, Hiroyuki, Takahashi, Kenichi, Satoh-Horikawa, Keiko, Tachibana, Kouichi, Takai, Yoshimi
• Format: Journal Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology 07.01.2000

We have recently found a novel functional unit of cell-cell adhesion at cadherin-based adherens junctions, consisting of at least nectin, a homophilic cell adhesion molecule, and afadin, an actin filament-binding protein, which connects nectin to the actin cytoskeleton. Here we studied a mechanism o...