Interference in immunoassay measurements of TSH and thyroid hormones after vaccine for Covid-19 or Covid-19 disease

Immunoassays are commonly used to measure thyroid-stimulating hormone (TSH) and thyroid hormone levels (TH). However, interference in these immunoassays may lead to the misinterpretation of patient results and incorrect therapeutic decisions. Analytical interference can occur following exposure to a...

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Published inMedicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma Zlatibor Vol. 28; no. 91; pp. 68 - 78
Main Authors Marković, Bojan, Petrović-Mucok, Ana, Klet, Sanja, Janić, Tamara, Babić, Jovana, Stojković, Mirjana, Nedeljković-Beleslin, Biljana, Cirić, Jasmina, Žarković, Miloš
Format Journal Article
LanguageEnglish
Published Specijalna bolnica za bolesti štitaste žlezde i bolesti metabolizma Zlatibor 2023
Subjects
covid-19
interference
thyroid hormones
tsh
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Summary:Immunoassays are commonly used to measure thyroid-stimulating hormone (TSH) and thyroid hormone levels (TH). However, interference in these immunoassays may lead to the misinterpretation of patient results and incorrect therapeutic decisions. Analytical interference can occur following exposure to animals, infections, vaccination, in autoimmune diseases, or without an identified cause. Analytical interference associated with COVID-19 exposure has been observed in D-dimer measurements. A dilution test was used to confirm interference in the measurement of TSH and TH levels. In three patients, interference in TSH and TH levels was detected after COVID-19 infection or vaccination. Conclusions: Owing to the high number of infected and vaccinated individuals, we can expect an increase in the prevalence of interference in immunometric methods.
ISSN:1821-1925
2406-131X
DOI:10.5937/mgiszm2391068M