A 4-week Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Use of Grape Seed Extract for Reducing Plasma Glucose, Lipid Profile, and Blood Pressure in Patients with Type 2 Diabetes Mellitus
: Diabetes mellitus (DM) is a common chronic disease that can significantly reduce life expectancy due to its complications. Grapes (Vitis vinifera L.) and their byproducts, including grape seeds, have been used worldwide for the treatment of various ailments. This clinical trial investigated the ef...
Saved in:
| Published in | Jundishapur journal of natural pharmaceutical products Vol. 19; no. 1 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
2024
|
| Online Access | Get full text |
Cover
Loading…
| Abstract | : Diabetes mellitus (DM) is a common chronic disease that can significantly reduce life expectancy due to its complications. Grapes (Vitis vinifera L.) and their byproducts, including grape seeds, have been used worldwide for the treatment of various ailments. This clinical trial investigated the effect of grape seed extract (GSE) on fasting blood sugar (FBS), lipid profile (including total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides [TG]), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with type 2 diabetes mellitus (T2DM). A total of 74 patients with T2DM were divided into two groups, including 38 patients in the treatment (GSE) group receiving 263.2 mg of GSE (standardized to 250 mg proanthocyanidin) twice daily and 36 patients in the placebo (control) group receiving 263.2 mg of the placebo twice daily for 30 days. At the end of the intervention, a statistically significant decrease was observed in SBP (from 125.83 ± 13.39 in the placebo group to 121.94 ± 7.49 in the treatment group, P = 0.002) and FBS (from 144.75 ± 30.82 in the placebo group to 129.87 ± 31.79 in the treatment group, P = 0.001). However, there were no significant changes in total cholesterol, HDL, LDL, TG, and DBP between the two groups. The use of Iranian GSE for a short period might lead to lower FBS and SBP. Therefore, GSE might play a significant role in improving blood pressure and fasting blood glucose levels in patients with T2DM. |
|---|---|
| AbstractList | : Diabetes mellitus (DM) is a common chronic disease that can significantly reduce life expectancy due to its complications. Grapes (Vitis vinifera L.) and their byproducts, including grape seeds, have been used worldwide for the treatment of various ailments. This clinical trial investigated the effect of grape seed extract (GSE) on fasting blood sugar (FBS), lipid profile (including total cholesterol, high-density lipoprotein [HDL], low-density lipoprotein [LDL], and triglycerides [TG]), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in patients with type 2 diabetes mellitus (T2DM). A total of 74 patients with T2DM were divided into two groups, including 38 patients in the treatment (GSE) group receiving 263.2 mg of GSE (standardized to 250 mg proanthocyanidin) twice daily and 36 patients in the placebo (control) group receiving 263.2 mg of the placebo twice daily for 30 days. At the end of the intervention, a statistically significant decrease was observed in SBP (from 125.83 ± 13.39 in the placebo group to 121.94 ± 7.49 in the treatment group, P = 0.002) and FBS (from 144.75 ± 30.82 in the placebo group to 129.87 ± 31.79 in the treatment group, P = 0.001). However, there were no significant changes in total cholesterol, HDL, LDL, TG, and DBP between the two groups. The use of Iranian GSE for a short period might lead to lower FBS and SBP. Therefore, GSE might play a significant role in improving blood pressure and fasting blood glucose levels in patients with T2DM. |
| Author | Saki Malehi, Amal Zaeemzadeh, Narjes Alavifar, Marzieh Zakerkish, Mehrnoosh |
| Author_xml | – sequence: 1 givenname: Narjes orcidid: 0000-0002-1162-7381 surname: Zaeemzadeh fullname: Zaeemzadeh, Narjes – sequence: 2 givenname: Marzieh surname: Alavifar fullname: Alavifar, Marzieh – sequence: 3 givenname: Amal orcidid: 0000-0002-0952-5861 surname: Saki Malehi fullname: Saki Malehi, Amal – sequence: 4 givenname: Mehrnoosh surname: Zakerkish fullname: Zakerkish, Mehrnoosh |
| BookMark | eNotUcFu1DAQtVCRWEpvfMB8wBpiJ06cY7ttF6RFrMpyjhxnTL147ch2VMpH8k14KXOY0XszejOa95Zc-OCRkPes-iAk4x-PRz_PlDWcC_6KrDjnknayay_IinW1oF0nqzfkKqVjVaKVTdeLFflzDQ19QvwJD8pP4WR_47SG27CMDumNs76gvVMax0A3wecYnMMJNqVjtXJwiLbk4CE_InxPCMHANqoZ4RuWubtfOSqdwYQIDzgt2vofZ710UrB1iw4J17Czs51gH4OxrsByB9y4EM4UprREBOthr7JFnxM82fwIh-eygcOtVSNmTPAFnbN5Se_Ia6Ncwqv_9ZIc7u8Om09093X7eXO9o5o1glNTnqHHVrTlB3XV87quWa97IyYpeFcYyQRvejbKfqpbqaWQ2I-Gm25kehrrS7J-kdUxpBTRDHO0JxWfB1YNZzeGf24ML27UfwHVFYBq |
| Cites_doi | 10.1248/jhs.49.45 10.1111/1750-3841.12066 10.1002/ptr.5104 10.1155/2012/981896 10.1016/j.foodchem.2022.134762 10.1017/S0007114515004328 10.2174/187152506778520691 10.1002/ptr.5570 10.1159/000191103 10.33263/lianbs93.11991207 10.1002/ptr.6859 10.1038/s41598-019-43838-8 10.1016/j.dsx.2020.12.028 10.3389/fmed.2022.995944 10.1097/MD.0000000000015515 10.2337/dc10-S062 10.3390/foods11182755 10.1111/j.1464-5491.2009.02727.x 10.1038/ejcn.2015.88 10.1016/j.metabol.2009.05.030 10.1016/s0899-9007(03)00167-9 10.1007/s11064-012-0821-2 10.3390/nu13051692 10.3109/09637486.2013.775228 10.1016/s0300-483x(00)00210-9 10.7860/jcdr/2021/45235.14792 10.1016/j.tcm.2019.05.003 10.1007/s13300-021-01152-5 10.1016/j.foodchem.2022.134405 10.2147/ijwr.S76162 |
| ContentType | Journal Article |
| DBID | AAYXX CITATION |
| DOI | 10.5812/jjnpp-142252 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | CrossRef |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 2228-7876 |
| ExternalDocumentID | 10_5812_jjnpp_142252 |
| GroupedDBID | --- AAYXX ADBBV ALMA_UNASSIGNED_HOLDINGS BAWUL CITATION DIK KQ8 M~E OK1 RNS RPM |
| ID | FETCH-LOGICAL-c1452-f778cb656795309233319c9f5d85273098152491b89d368c858e9bf2f7b1cdb3 |
| ISSN | 1735-7780 |
| IngestDate | Wed Nov 06 13:19:07 EST 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c1452-f778cb656795309233319c9f5d85273098152491b89d368c858e9bf2f7b1cdb3 |
| ORCID | 0000-0002-1162-7381 0000-0002-0952-5861 |
| OpenAccessLink | https://brieflands.com/articles/jjnpp-142252.pdf |
| ParticipantIDs | crossref_primary_10_5812_jjnpp_142252 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-00-00 |
| PublicationDateYYYYMMDD | 2024-01-01 |
| PublicationDate_xml | – year: 2024 text: 2024-00-00 |
| PublicationDecade | 2020 |
| PublicationTitle | Jundishapur journal of natural pharmaceutical products |
| PublicationYear | 2024 |
| References | key-A142252REF5-5 key-A142252REF6-6 key-A142252REF3-3 key-A142252REF4-4 Mansouri E (key-A142252REF21-21) 2011; 15 key-A142252REF1-1 key-A142252REF28-28 key-A142252REF20-20 key-A142252REF24-24 key-A142252REF22-22 key-A142252REF14-14 key-A142252REF12-12 key-A142252REF18-18 key-A142252REF16-16 key-A142252REF33-33 key-A142252REF31-31 key-A142252REF10-10 Centers for Disease Control (key-A142252REF2-2) 2022 key-A142252REF30-30 key-A142252REF27-27 key-A142252REF29-29 key-A142252REF25-25 key-A142252REF23-23 Pourghassem-Gargari B (key-A142252REF26-26) 2011; 5 key-A142252REF9-9 key-A142252REF13-13 key-A142252REF11-11 key-A142252REF19-19 key-A142252REF15-15 key-A142252REF17-17 key-A142252REF7-7 key-A142252REF32-32 key-A142252REF8-8 |
| References_xml | – ident: key-A142252REF30-30 doi: 10.1248/jhs.49.45 – ident: key-A142252REF8-8 doi: 10.1111/1750-3841.12066 – ident: key-A142252REF23-23 doi: 10.1002/ptr.5104 – ident: key-A142252REF4-4 doi: 10.1155/2012/981896 – volume: 5 start-page: 2029 issue: 10 year: 2011 ident: key-A142252REF26-26 publication-title: Journal of Medicinal Plants Research. contributor: fullname: Pourghassem-Gargari B – ident: key-A142252REF7-7 doi: 10.1016/j.foodchem.2022.134762 – ident: key-A142252REF31-31 doi: 10.1017/S0007114515004328 – ident: key-A142252REF12-12 doi: 10.2174/187152506778520691 – year: 2022 ident: key-A142252REF2-2 publication-title: National diabetes statistics report website. contributor: fullname: Centers for Disease Control – ident: key-A142252REF6-6 doi: 10.1002/ptr.5570 – ident: key-A142252REF22-22 doi: 10.1159/000191103 – ident: key-A142252REF5-5 doi: 10.33263/lianbs93.11991207 – ident: key-A142252REF33-33 doi: 10.1002/ptr.6859 – ident: key-A142252REF1-1 doi: 10.1038/s41598-019-43838-8 – ident: key-A142252REF16-16 doi: 10.1016/j.dsx.2020.12.028 – ident: key-A142252REF32-32 doi: 10.3389/fmed.2022.995944 – ident: key-A142252REF20-20 doi: 10.1097/MD.0000000000015515 – ident: key-A142252REF27-27 doi: 10.2337/dc10-S062 – ident: key-A142252REF9-9 doi: 10.3390/foods11182755 – ident: key-A142252REF19-19 doi: 10.1111/j.1464-5491.2009.02727.x – ident: key-A142252REF17-17 doi: 10.1038/ejcn.2015.88 – ident: key-A142252REF18-18 doi: 10.1016/j.metabol.2009.05.030 – ident: key-A142252REF11-11 doi: 10.1016/s0899-9007(03)00167-9 – ident: key-A142252REF13-13 doi: 10.1007/s11064-012-0821-2 – ident: key-A142252REF24-24 doi: 10.3390/nu13051692 – ident: key-A142252REF29-29 doi: 10.3109/09637486.2013.775228 – ident: key-A142252REF15-15 doi: 10.1016/s0300-483x(00)00210-9 – ident: key-A142252REF25-25 doi: 10.7860/jcdr/2021/45235.14792 – volume: 15 start-page: 100 issue: 3 year: 2011 ident: key-A142252REF21-21 publication-title: Iranian biomedical journal. contributor: fullname: Mansouri E – ident: key-A142252REF28-28 doi: 10.1016/j.tcm.2019.05.003 – ident: key-A142252REF3-3 doi: 10.1007/s13300-021-01152-5 – ident: key-A142252REF14-14 doi: 10.1016/j.foodchem.2022.134405 – ident: key-A142252REF10-10 doi: 10.2147/ijwr.S76162 |
| SSID | ssj0000684795 |
| Score | 2.3152971 |
| Snippet | : Diabetes mellitus (DM) is a common chronic disease that can significantly reduce life expectancy due to its complications. Grapes (Vitis vinifera L.) and... |
| SourceID | crossref |
| SourceType | Aggregation Database |
| Title | A 4-week Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Use of Grape Seed Extract for Reducing Plasma Glucose, Lipid Profile, and Blood Pressure in Patients with Type 2 Diabetes Mellitus |
| Volume | 19 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEF615QIHxFOUl-YAvcQujl-xj-mDFlBQVVyp4hLt2mslbWJbTgI0P5LfxOyO7Tihh8LFilbejeX5sjPzZeZbxt7x1OmhZ5CmJWPHdIUlTNG1pCkcmwsnDRNXd6UNvvqnF-7nS-9ya_tBq2ppMRf78fLWvpL_sSqOoV1Vl-w_WLZZFAfwM9oXr2hhvN7Jxv2Oa_6U8rpzzrMkn46XxFxiUCwm0jzACJKiREWVi9w8pLL0iSJ164bISJ_aQf8YdC6I2D9RHVm4i-B9x7_mqo1KFyOeK5VXxSzgerMp75xQtTtl9sVYNx2QzBMVhB6omviq_7DU2iRnJOJaddRFxP4e1ezvQGmDzisioo6XF1mizocuFmVb5ELLkaoestEaI1-QfG2TJnznUk6XPJEjciTl1apisj_hP8YplZcPeLkcy4YY_4ZRNY5NpD7wuNOf8slqxWtZYsytFxzIUZnl-WzUpk6oV7va53tKqbNHh0jtSz2muDAT9y9_zTmEmz-CTZ_jYYikfM5VVhSmYtRIkXdd2nvD5TaFkJiCqflDPXtIs7fZPRt3TVWfevTpS0MYWj4GEvoUoebhqZFDLfCh_fWtEKsVK0WP2MMqyYE-IfYx25LZE7Z3Rsa6MSBaNf3NDNiDs5V--s1T9rsPBGtYwdqANqgN-BvSUEMaNKQhzwAhDQhpyFPQkAYFaaggDQhpqCENBGmoIG2ABjRUgDYAnwM0nKGGM4wzqOEMCs6g4Aw21HCGGs7PWPTxODo8NatjR8y463q2meKrjQXmOfi2HQsTIAfdVBymXhIotUIrDDDmdcOuCMLE8YM48AIZitROe6IbJ8J5znayPJMvGGCkh9kI7zpcJq6f2sLjPfSBgYNBti19vsve14YaFiQuM7wNES_veN8rdl_BnBjC12xnXi7kG4yZ5-KtxtIftR3J-g |
| link.rule.ids | 315,783,787,4031,27935,27936,27937 |
| linkProvider | Flying Publisher |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+4-week+Randomized%2C+Double-Blind%2C+Placebo-Controlled+Clinical+Trial+on+the+Use+of+Grape+Seed+Extract+for+Reducing+Plasma+Glucose%2C+Lipid+Profile%2C+and+Blood+Pressure+in+Patients+with+Type+2+Diabetes+Mellitus&rft.jtitle=Jundishapur+journal+of+natural+pharmaceutical+products&rft.au=Zaeemzadeh%2C+Narjes&rft.au=Alavifar%2C+Marzieh&rft.au=Saki+Malehi%2C+Amal&rft.au=Zakerkish%2C+Mehrnoosh&rft.date=2024&rft.issn=1735-7780&rft.eissn=2228-7876&rft.volume=19&rft.issue=1&rft_id=info:doi/10.5812%2Fjjnpp-142252&rft.externalDBID=n%2Fa&rft.externalDocID=10_5812_jjnpp_142252 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1735-7780&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1735-7780&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1735-7780&client=summon |