Vitamin D(3) regulates hepatic VEGF-A and apelin expression in experimental type 1 diabetes
The deficiency of vitamin D is associated with the risk of various chronic diseases, including diabetes mellitus and its complications. Given the strong genomic action of vitamin D hormone-active form, its deficiency can lead to dysfunction of cytokine signaling pathways, including those dependent o...
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Published in | Ukrainian biochemical journal Vol. 92; no. 4; pp. 5 - 13 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
10.09.2020
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Abstract | The deficiency of vitamin D is associated with the risk of various chronic diseases, including diabetes mellitus and its complications. Given the strong genomic action of vitamin D hormone-active form, its deficiency can lead to dysfunction of cytokine signaling pathways, including those dependent on vascular endothelial growth factors (VEGFs) and apelin. The present study was carried out to define the link between VEGF-A and apelin expression in liver, hepatocytes viability and vitamin D status at experimental type 1 diabetes in mice. We established that chronic hyperglycemia at streptozotocin-induced diabetes was accompanied by a 2.2-fold decrease in 25OHD content in the serum and increased hepatocytes apoptosis and necrosis. Vitamin D deficiency correlated with increased apelin and VEGF-A (8- and 1.6-fold respectively) expression. Almost complete restoration of circulatory 25OHD content in serum was achieved at vitamin D3 treatment (800 IU/kg, per os, for 2 months) followed by reduced apelin and VEGF-A expression in liver and the decline of hepatocytes apoptosis. We conclude that vitamin D3 can be involved in cell survival, angiogenesis and fibrogenesis by modulating VEGF-A and apelin dependent regulatory systems in diabetic liver. |
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AbstractList | The deficiency of vitamin D is associated with the risk of various chronic diseases, including diabetes mellitus and its complications. Given the strong genomic action of vitamin D hormone-active form, its deficiency can lead to dysfunction of cytokine signaling pathways, including those dependent on vascular endothelial growth factors (VEGFs) and apelin. The present study was carried out to define the link between VEGF-A and apelin expression in liver, hepatocytes viability and vitamin D status at experimental type 1 diabetes in mice. We established that chronic hyperglycemia at streptozotocin-induced diabetes was accompanied by a 2.2-fold decrease in 25OHD content in the serum and increased hepatocytes apoptosis and necrosis. Vitamin D deficiency correlated with increased apelin and VEGF-A (8- and 1.6-fold respectively) expression. Almost complete restoration of circulatory 25OHD content in serum was achieved at vitamin D3 treatment (800 IU/kg, per os, for 2 months) followed by reduced apelin and VEGF-A expression in liver and the decline of hepatocytes apoptosis. We conclude that vitamin D3 can be involved in cell survival, angiogenesis and fibrogenesis by modulating VEGF-A and apelin dependent regulatory systems in diabetic liver. |
Author | Natrus, L. V. Lisakovska, O. O. Shymanskyi, I. O. Labudzynskyi, D. O. Mazanova, A. O. Veliky, M. M. |
Author_xml | – sequence: 1 givenname: D. O. surname: Labudzynskyi fullname: Labudzynskyi, D. O. – sequence: 2 givenname: I. O. surname: Shymanskyi fullname: Shymanskyi, I. O. – sequence: 3 givenname: O. O. surname: Lisakovska fullname: Lisakovska, O. O. – sequence: 4 givenname: A. O. surname: Mazanova fullname: Mazanova, A. O. – sequence: 5 givenname: L. V. surname: Natrus fullname: Natrus, L. V. – sequence: 6 givenname: M. M. surname: Veliky fullname: Veliky, M. M. |
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Cites_doi | 10.1002/hep.22467 10.4254/wjh.v6.i12.901 10.2337/db06-0880 10.1038/nrendo.2017.173 10.1155/2016/1925424 10.1002/mnfr.201100623 10.1002/jcb.28185 10.1002/jcp.27720 10.1126/science.180605 10.1155/2012/918267 10.1016/j.biocel.2015.10.015 10.1002/hep.22541 10.1152/physrev.00014.2015 10.1016/j.npep.2016.08.006 10.1016/j.atherosclerosis.2008.08.020 10.1051/jbio/2009021 10.18295/squmj.2016.16.02.002 10.5114/ceji.2014.43732 10.18632/oncotarget.22841 10.1152/ajpheart.00319.2017 10.2174/1389203718666170918154728 10.1053/j.gastro.2014.01.061 10.5754/hge10845 10.1016/j.jsbmb.2015.04.003 10.2147/VHRM.S1991 10.1016/j.mehy.2016.09.001 10.1007/s11062-017-9672-4 10.1016/j.ejphar.2015.05.017 10.3389/fphar.2017.00221 10.3389/fendo.2018.00600 10.1155/2018/2494016 10.3892/ijmm.2016.2544 10.1016/j.ymgme.2016.07.012 10.1016/j.cca.2016.02.025 |
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Title | Vitamin D(3) regulates hepatic VEGF-A and apelin expression in experimental type 1 diabetes |
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