Short‐term in vivo modifications of platelet NADPH oxidase 2 ( NOX 2) and prostaglandin F 2α in HIV‐1 patients on abacavir‐based therapies

• Published in: HIV medicine Vol. 17; no. 10; pp. 774 - 777
• Main Authors: Pastori, D, Esposito, A, Carnevale, R, Bartimoccia, S, Nocella, C, Fantauzzi, A, Pignatelli, P, Violi, F, Mezzaroma, I
• Format: Journal Article
• Language: English
• Published: England 01.11.2016
• Subjects: Adolescent; Adult; Anti-HIV Agents - therapeutic use; Blood Platelets - chemistry; Blood Platelets - enzymology; CD40 Ligand - blood; Dideoxynucleosides - therapeutic use; Dinoprost - analysis; Female; HIV Infections - drug therapy; HIV Infections - pathology; Humans; Male; Membrane Glycoproteins - analysis; Middle Aged; NADPH Oxidase 2; NADPH Oxidases - analysis; Pilot Projects; Platelet Activation; Young Adult; abacavir; HIV-1 infection; isoprostanes; NADPH oxidase; platelet activation

The aim of the study was to investigate the in vivo effect of abacavir (ABC) on platelet oxidative stress. We performed a randomized pilot study including 39 HIV-1-infected patients, 17 on zidovudine/lamivudine (ZDV/3TC) and 22 on tenofovir/emtricitabine (TDF/FTC). Ten patients on ZDV/3TC and eight...