U2AF1 Driver Mutations in Hematopoietic Disorders Alter but Do Not Abrogate RNA Binding and Enlighten Structural Dependencies of the U2AF-RNA Complex

• Published in: Blood Vol. 134; no. Supplement_1; p. 1230
• Main Authors: Biancon, Giulia, Joshi, Poorval, Hunck, Torben, Gao, Yimeng, Botti, Valentina, Qin, Ashley, Sadykov, Mukhtar, Wang, Xiaman, Viero, Gabriella, Neuenkirchen, Nils, Taylor, Ashley, Huang, Jane, Ardasheva, Anastasia, Fu, Xiaoying, Lin, Haifan, Pillai, Manoj M, Kielkopf, Clara L, Neugebauer, Karla M, Tebaldi, Toma, Halene, Stephanie
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.11.2019

Among genetic aberrations responsible for ineffective hematopoiesis in myelodysplastic syndromes (MDS) and acute myeloid leukemia, somatic mutations in splicing factors such as U2AF1 are of significant interest as they are recurrent, mutually exclusive and early occurring. U2AF1 participates in mRNA...