Time Limited Exposure to a ROR1 Targeting Bispecific T Cell Engager (NVG-111) Leads to Durable Responses in Subjects with Relapsed Refractory Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL)

• Published in: Blood Vol. 142; no. Supplement 1; p. 329
• Main Authors: Townsend, William, Leong, Sarah, Shah, Mittal, Batten, Toby, Tucker, David, Pottinger, Bryson, Paneesha, Shankaranarayana, El-Sharkawi, Dima, Eyre, Toby A., Lam, Ho Pui Jeff, Zheng, Jiexin, Cook, Sarah, Granger, David, Ahern, David, O'Donovan, Kieran, Nathwani, Amit C., Jasani, Parag
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 02.11.2023

Background: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncofetal protein that is absent or expressed at low levels in normal adult tissues but overexpressed in a range of malignancies including CLL and MCL. NVG-111 is a humanized first in class, tandem scFv, ROR1xCD3 bispecific T c...