BIOM-04. SENSITIVE DETECTION OF LEPTOMENINGEAL DISEASE USING CELL-FREE DNA FROM CEREBROSPINAL FLUID

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 23; no. Supplement_6; p. vi10
• Main Authors: White, Michael, Klein, Robert, Shaw, Brian, Kim, Albert, Subramanian, Megha, Mora, Joana, Giobbie-Hurder, Anita, Nagabhushan, Deepika, Jain, Aarushi, Singh, Mohini, Kuter, Benjamin, Nayyar, Naema, Stocking, Jackson, Markson, Samuel, Lastrapes, Matthew, Alvarez-Breckenridge, Christopher, Cahill, Daniel, Mahar, Maura, Rhoades, Justin, Rotam, Denisse, Bertalan, Mia, Gydush, Greg, Adalsteinsson, Viktor, Kaplan, Alexander, Oh, Kevin, Sullivan, Ryan, Gerstner, Elizabeth, Carter, Scott, Brastianos, Priscilla
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 12.11.2021

Abstract Leptomeningeal disease is a devastating complication of cancer that is frequently underdiagnosed due to the low sensitivity of cerebrospinal fluid cytology, the current gold-standard diagnostic method. We performed genomic sequencing on cerebrospinal fluid specimens obtained from patients w...