Inclacumab Reduce Preexisting Red Blood Cell Adhesion to Activated Endothelial Cells: In-Vitro Assessment of the Microfluidic Platform Endothelium-on-a-Chip

• Published in: Blood Vol. 142; no. Supplement 1; p. 5267
• Main Authors: Federici, Chiara, Spehn, Madelyn, Kovshovik, Pavel, Opheim, Kara, Combs, Gabrielle, Sertel, Seniye, Braxton, Samantha J, Bode, Allison, Zak, John, Geng, Xin, Gurkan, Umut A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 02.11.2023

Background: In 2019 FDA approved the use of an antibody anti P-selectin (Crizanlizumab) for the treatment of sickle cell disease (SCD) to reduce the vaso occlusive crisis (VOCs). New anti-adhesive treatments are being developed recently. Global Blood Therapeutics, Inc., acquired by Pfizer Inc. in Oc...