Noncollapsibility of the odds ratio unraveled

Purpose of review The concept of noncollapsibility of the odds ratio has intrigued the epidemiology community for decades. Despite often being overlooked or negatively perceived, which can lead researchers to prefer collapsible measures, this study highlights the beneficial aspects of noncollapsibil...

Full description

Saved in:
Bibliographic Details
Published inCurrent Opinion in Epidemiology and Public Health
Main Authors Abdulmajeed, Jazeel, Kostoulas, Polychronis, Shi, Zumin, Doi, Suhail A.R.
Format Journal Article
LanguageEnglish
Published 08.08.2023
Online AccessGet full text

Cover

Abstract Purpose of review The concept of noncollapsibility of the odds ratio has intrigued the epidemiology community for decades. Despite often being overlooked or negatively perceived, which can lead researchers to prefer collapsible measures, this study highlights the beneficial aspects of noncollapsibility of the odds ratio. Recent findings This study links recent diagnostic test research with effect measures. Noncollapsibility is a useful characteristic, and its understanding can have important implications in medical research. Summary We demonstrate that a change in effect could be due to confounding, noncollapsibility, or a combination of both and that noncollapsibility can be a powerful tool for data analysis and interpretation when properly understood. This study aims to help researchers demystify this complex issue and offers updated recommendations.
AbstractList Purpose of review The concept of noncollapsibility of the odds ratio has intrigued the epidemiology community for decades. Despite often being overlooked or negatively perceived, which can lead researchers to prefer collapsible measures, this study highlights the beneficial aspects of noncollapsibility of the odds ratio. Recent findings This study links recent diagnostic test research with effect measures. Noncollapsibility is a useful characteristic, and its understanding can have important implications in medical research. Summary We demonstrate that a change in effect could be due to confounding, noncollapsibility, or a combination of both and that noncollapsibility can be a powerful tool for data analysis and interpretation when properly understood. This study aims to help researchers demystify this complex issue and offers updated recommendations.
Author Abdulmajeed, Jazeel
Kostoulas, Polychronis
Doi, Suhail A.R.
Shi, Zumin
Author_xml – sequence: 1
  givenname: Jazeel
  surname: Abdulmajeed
  fullname: Abdulmajeed, Jazeel
  organization: Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar
– sequence: 2
  givenname: Polychronis
  surname: Kostoulas
  fullname: Kostoulas, Polychronis
  organization: Laboratory of Epidemiology and Artificial Intelligence, Faculty of Public Health, University of Thessaly, Thessaly, Greece
– sequence: 3
  givenname: Zumin
  surname: Shi
  fullname: Shi, Zumin
  organization: Department of Human Nutrition, College of Health Sciences, QU Health, Qatar University, Doha, Qatar
– sequence: 4
  givenname: Suhail A.R.
  surname: Doi
  fullname: Doi, Suhail A.R.
  organization: Department of Population Medicine, College of Medicine, QU Health, Qatar University, Doha, Qatar
BookMark eNpdj81KAzEUhYNUsNa-gYt5gam5N5n8LKWoLRTtooK7IU3u4ECclGQU-vZWdKGezTl8iwPfJZsMaSDGroEvgFt9s31ZLfifIJ6xKWqlagsGJr_2BZuX0u95w8HyBvSU1Y9p8ClGdzjxPvbjsUpdNb5SlUIoVXZjn6r3IbsPihSu2HnnYqH5T8_Y8_3dbrmqN08P6-XtpvYgEWuUKCWSA1IYzN6AQschcB-8VR2R9FqTEGTQSNF0wWovDCDaJiDXQYgZk9-_PqdSMnXtIfdvLh9b4O2XdXuybv9bi0_X90q5
CitedBy_id crossref_primary_10_1016_j_canep_2023_102521
Cites_doi 10.1177/0962280213505804
10.1016/j.jclinepi.2021.06.004
10.1214/ss/1009211805
10.1002/sim.1099
10.1111/jebm.12495
10.1093/oxfordjournals.aje.a114593
10.1002/bimj.202000202
10.1016/j.jclinepi.2020.08.019
10.1177/09622802211034219
10.1016/S0002-8703(00)90001-2
10.1016/j.amjcard.2012.09.002
10.3310/hta5330
10.1097/00001648-199701000-00002
10.1080/01621459.2016.1192546
10.1016/j.jclinepi.2021.08.003
10.2188/jea.JE20130062
10.1186/s12874-021-01316-8
10.1002/bimj.201900297
10.1016/j.jclinepi.2021.06.007
10.1093/aje/kwaa267
10.1186/s12874-020-01145-1
10.1002/sim.6739
ContentType Journal Article
DBID AAYXX
CITATION
DOI 10.1097/PXH.0000000000000022
DatabaseName CrossRef
DatabaseTitle CrossRef
DatabaseTitleList CrossRef
DeliveryMethod fulltext_linktorsrc
EISSN 2766-9181
ExternalDocumentID 10_1097_PXH_0000000000000022
GroupedDBID AAAAV
AAIQE
AASCR
AAYXX
ABVCZ
ACILI
ACXJB
ADGGA
ADHPY
ADPDF
AHQNM
AINUH
AJNWD
AJZMW
ALMA_UNASSIGNED_HOLDINGS
AMJPA
AMKUR
AMNEI
AOHHW
CITATION
DIWNM
EEVPB
FCALG
GNXGY
GQDEL
IKREB
OVD
OVDNE
OVEED
RLZ
TEORI
TSPGW
ID FETCH-LOGICAL-c1422-242442ea1e62d8b8162a01d0cdc96fee4c77e33e828435fd97c3812295d207d33
ISSN 2766-9181
IngestDate Wed Aug 28 12:31:54 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Language English
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c1422-242442ea1e62d8b8162a01d0cdc96fee4c77e33e828435fd97c3812295d207d33
OpenAccessLink https://doi.org/10.1097/pxh.0000000000000022
ParticipantIDs crossref_primary_10_1097_PXH_0000000000000022
PublicationCentury 2000
PublicationDate 2023-08-08
PublicationDateYYYYMMDD 2023-08-08
PublicationDate_xml – month: 08
  year: 2023
  text: 2023-08-08
  day: 08
PublicationDecade 2020
PublicationTitle Current Opinion in Epidemiology and Public Health
PublicationYear 2023
References Doi (R27-20240826) 2022; 142
Moons (R14-20240826) 1997; 8
Senn (R25-20240826) 2016; 35
Brookes (R24-20240826) 2001; 5
Richardson (R13-20240826) 2017; 112
Greenland (R10-20240826) 1999; 14
Steyerberg (R21-20240826) 2000; 139
Whitcomb (R5-20240826) 2021; 190
Pang (R8-20240826) 2013; 111
Schuster (R4-20240826) 2021; 21
Doi (R23-20240826) 2022; 15
Greenland (R1-20240826) 2021; 139
Cornfield (R12-20240826) 1959; 22
Walter (R16-20240826) 2002; 21
Talbot (R17-20240826) 2021; 30
Pang (R20-20240826) 2016; 25
Greenland (R2-20240826) 1987; 125
Doi (R26-20240826) 2022; 142
Doi (R11-20240826) 2023; 28
Daniel (R9-20240826) 2021; 63
Lee (R19-20240826) 2014; 24
Greenland (R3-20240826) 2021; 138
Rekkas (R22-20240826) 2020; 20
Liu (R6-20240826) 2022; 64
References_xml – volume: 25
  start-page: 1925
  year: 2016
  ident: R20-20240826
  article-title: Studying noncollapsibility of the odds ratio with marginal structural and logistic regression models
  publication-title: Stat Methods Med Res
  doi: 10.1177/0962280213505804
  contributor:
    fullname: Pang
– volume: 139
  start-page: 264
  year: 2021
  ident: R1-20240826
  article-title: Noncollapsibility, confounding, and sparse-data bias. Part 2: What should researchers make of persistent controversies about the odds ratio?
  publication-title: J Clin Epidemiol
  doi: 10.1016/j.jclinepi.2021.06.004
  contributor:
    fullname: Greenland
– volume: 14
  start-page: 29
  year: 1999
  ident: R10-20240826
  article-title: Confounding and collapsibility in causal inference
  publication-title: Statist Sci
  doi: 10.1214/ss/1009211805
  contributor:
    fullname: Greenland
– volume: 21
  start-page: 1237
  year: 2002
  ident: R16-20240826
  article-title: Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data
  publication-title: Stat Med
  doi: 10.1002/sim.1099
  contributor:
    fullname: Walter
– volume: 15
  start-page: 192
  year: 2022
  ident: R23-20240826
  article-title: Redefining effect modification
  publication-title: J Evid Based Med
  doi: 10.1111/jebm.12495
  contributor:
    fullname: Doi
– volume: 125
  start-page: 761
  year: 1987
  ident: R2-20240826
  article-title: Interpretation and choice of effect measures in epidemiologic analyses
  publication-title: Am J Epidemiol
  doi: 10.1093/oxfordjournals.aje.a114593
  contributor:
    fullname: Greenland
– volume: 64
  start-page: 198
  year: 2022
  ident: R6-20240826
  article-title: Correct and logical causal inference for binary and time-to-event outcomes in randomized controlled trials
  publication-title: Biometrical J
  doi: 10.1002/bimj.202000202
  contributor:
    fullname: Liu
– volume: 142
  start-page: 271
  year: 2022
  ident: R26-20240826
  article-title: Controversy and debate: questionable utility of the relative risk in clinical research: Paper 1: a call for change to practice
  publication-title: J Clin Epidemiol
  doi: 10.1016/j.jclinepi.2020.08.019
  contributor:
    fullname: Doi
– volume: 30
  start-page: 2032
  year: 2021
  ident: R17-20240826
  article-title: The change in estimate method for selecting confounders: a simulation study
  publication-title: Stat Methods Med Res
  doi: 10.1177/09622802211034219
  contributor:
    fullname: Talbot
– volume: 139
  start-page: 745
  year: 2000
  ident: R21-20240826
  article-title: Clinical trials in acute myocardial infarction: should we adjust for baseline characteristics?
  publication-title: Am Heart J
  doi: 10.1016/S0002-8703(00)90001-2
  contributor:
    fullname: Steyerberg
– volume: 111
  start-page: 302
  year: 2013
  ident: R8-20240826
  article-title: Mixing of confounding and non-collapsibility: a notable deficiency of the odds ratio
  publication-title: Am J Cardiol
  doi: 10.1016/j.amjcard.2012.09.002
  contributor:
    fullname: Pang
– volume: 5
  start-page: 1
  year: 2001
  ident: R24-20240826
  article-title: Subgroup analyses in randomised controlled trials: quantifying the risks of false-positives and false-negatives
  publication-title: Health Technol Assess
  doi: 10.3310/hta5330
  contributor:
    fullname: Brookes
– volume: 22
  start-page: 173
  year: 1959
  ident: R12-20240826
  article-title: Smoking and lung cancer: recent evidence and a discussion of some questions
  publication-title: J Natl Cancer Inst
  contributor:
    fullname: Cornfield
– volume: 8
  start-page: 12
  year: 1997
  ident: R14-20240826
  article-title: Limitations of sensitivity, specificity, likelihood ratio, and bayes’ theorem in assessing diagnostic probabilities: a clinical example
  publication-title: Epidemiology
  doi: 10.1097/00001648-199701000-00002
  contributor:
    fullname: Moons
– volume: 112
  start-page: 1121
  year: 2017
  ident: R13-20240826
  article-title: On modeling and estimation for the relative risk and risk difference
  publication-title: J Am Stat Assoc
  doi: 10.1080/01621459.2016.1192546
  contributor:
    fullname: Richardson
– volume: 142
  start-page: 288
  year: 2022
  ident: R27-20240826
  article-title: The odds ratio is “portable” across baseline risk but not the relative risk: time to do away with the log link in binomial regression
  publication-title: J Clin Epidemiol
  doi: 10.1016/j.jclinepi.2021.08.003
  contributor:
    fullname: Doi
– volume: 24
  start-page: 161
  year: 2014
  ident: R19-20240826
  article-title: Is a cutoff of 10% appropriate for the change-in-estimate criterion of confounder identification?
  publication-title: J Epidemiol
  doi: 10.2188/jea.JE20130062
  contributor:
    fullname: Lee
– volume: 28
  start-page: 241
  year: 2023
  ident: R11-20240826
  article-title: Likelihood ratio interpretation of the relative risk
  publication-title: BMJ
  contributor:
    fullname: Doi
– volume: 21
  start-page: 136
  year: 2021
  ident: R4-20240826
  article-title: Noncollapsibility and its role in quantifying confounding bias in logistic regression
  publication-title: BMC Med Res Methodol
  doi: 10.1186/s12874-021-01316-8
  contributor:
    fullname: Schuster
– volume: 63
  start-page: 528
  year: 2021
  ident: R9-20240826
  article-title: Making apples from oranges: comparing noncollapsible effect estimators and their standard errors after adjustment for different covariate sets
  publication-title: Biom J
  doi: 10.1002/bimj.201900297
  contributor:
    fullname: Daniel
– volume: 138
  start-page: 178
  year: 2021
  ident: R3-20240826
  article-title: Noncollapsibility, confounding, and sparse-data bias Part 1: The oddities of odds
  publication-title: J Clin Epidemiol
  doi: 10.1016/j.jclinepi.2021.06.007
  contributor:
    fullname: Greenland
– volume: 190
  start-page: 697
  year: 2021
  ident: R5-20240826
  article-title: Defining, quantifying, and interpreting “Noncollapsibility” in epidemiologic studies of measures of “Effect”
  publication-title: Am J Epidemiol
  doi: 10.1093/aje/kwaa267
  contributor:
    fullname: Whitcomb
– volume: 20
  start-page: 264
  year: 2020
  ident: R22-20240826
  article-title: Predictive approaches to heterogeneous treatment effects: a scoping review
  publication-title: BMC Med Res Methodol
  doi: 10.1186/s12874-020-01145-1
  contributor:
    fullname: Rekkas
– volume: 35
  start-page: 966
  year: 2016
  ident: R25-20240826
  article-title: Mastering variation: variance components and personalised medicine
  publication-title: Stat Med
  doi: 10.1002/sim.6739
  contributor:
    fullname: Senn
SSID ssib050190517
Score 2.2711747
Snippet Purpose of review The concept of noncollapsibility of the odds ratio has intrigued the epidemiology community for decades. Despite often being overlooked or...
SourceID crossref
SourceType Aggregation Database
Title Noncollapsibility of the odds ratio unraveled
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3PS8MwFA66XbyIouJvevA2Wrs0bZqjuMmYoKJThpeRJSlOZjt0Pehf70vTdt0m4uyhhFBC2-_r60vy3vcQOvOxYtQjzCbSJTaJJLe553NoCRZJ4SmXZ2qfN0HnkXT7fn-Wrphll0yHjvj6Ma_kP6hCH-Cqs2RXQLYcFDqgDfjCGRCG858wvkniDMdJHuP6Wez4J1J-NDJsG2msCwyN5wtyFqpMt5NRnAc7tmelYo0kk1nQy_OUZrtEMh2_8Vdl1ki7_EupMkbjWot0pGOTInaXjMG0auXd0mt_yAoIN57Tt1FJyVYyMsFBL3wEZHHuneo6BPayKLiK6cQ0CMB0mgIsjlruWzLWRgT4rt8xIpLlYRKV57WxF_5ZZSRhsYcOowwWR1lHdUyZD1Py-u1Tu90q7Iyv8-f9rBhzeYNFViWj5z_dUMVrqbgfvS20mc8brAtDgm20puIdZC8RwEoiCwhgaQJYGQGskgC76PGq3bvs2Hn9C1volTm9W08IVrypAizDYdgMMHeb0hVSsCBSighKlecpmDSD0xtJRgX4X7o-u8QulZ63h2pxEqt9ZEkKnyE8HIPPj_i-CgPWlENoYxoK6oYHyC6ebzAxMieD317t4YrXH6GNGWeOUW36nqoT8Oamw9McnG9V70LH
link.rule.ids 315,786,790,27957,27958
linkProvider Ovid
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Noncollapsibility+of+the+odds+ratio+unraveled&rft.jtitle=Current+Opinion+in+Epidemiology+and+Public+Health&rft.au=Abdulmajeed%2C+Jazeel&rft.au=Kostoulas%2C+Polychronis&rft.au=Shi%2C+Zumin&rft.au=Doi%2C+Suhail+A.R.&rft.date=2023-08-08&rft.issn=2766-9181&rft.eissn=2766-9181&rft_id=info:doi/10.1097%2FPXH.0000000000000022&rft.externalDBID=n%2Fa&rft.externalDocID=10_1097_PXH_0000000000000022
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2766-9181&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2766-9181&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2766-9181&client=summon