Recurrent Crebbp Mutations in Follicular Lymphoma Appear Localized to the Committed B-Cell Lineage

• Published in: Blood Vol. 136; no. Supplement 1; pp. 30 - 31
• Main Authors: Schroers-Martin, Joseph G, Soo, Joanne, Brisou, Gabriel, Scherer, Florian, Kurtz, David M., Sworder, Brian, Khodadoust, Michael S., Jin, Michael C., Bru, Agnès, Liu, Chih Long, Stehr, Henning, Vineis, Paolo, Natkunam, Yasodha, Nadel, Bertrand, Diehn, Maximilian, Roulland, Sandrine, Alizadeh, Ash A.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 05.11.2020

Background: Follicular lymphoma (FL) is genetically characterized by translocations involving the BCL2 locus on chromosome 18q21. However, up to 70% of healthy individuals also carry detectable t(14;18)-positive cells, suggesting BCL2 translocation is critical but not sufficient for FL development....