Comparative Somatic Mutational Profiling of CD34+ Hematopoietic Precursors (HSC) and Circulating Endothelial Cells (CEC) in Patients with Primary Myelofibrosis (PMF)

• Published in: Blood Vol. 134; no. Supplement_1; p. 1684
• Main Authors: Farina, Mirko, Bernardi, Simona, Polverelli, Nicola, Zanaglio, Camilla, Malagola, Michele, Re, Federica, Cattina, Federica, D'Adda, Mariella, Rossi, Giuseppe, Zollner, Tatiana, Dunbar, Andrew, Levine, Ross L., Russo, Domenico
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 13.11.2019

INTRODUCTION Endothelial cells (EC) play an important role in thrombosis and are increased in frequency in Myeloproliferative Neoplasms (MPN). Notably, the JAK2V617F mutation has been identified in micro-laser-dissected EC in peripheral vasculature (Sozer, 2009) and is present in a subset of endothe...